{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:19:03Z","timestamp":1791670743987,"version":"4.3.4"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,9,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">All of Us is a novel research program that aims to accelerate research in populations traditionally underrepresented in biomedical research. Our objective was to evaluate the burden of cardiovascular disease (CVD) in broadly defined underrepresented groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">We evaluated the latest data release of All of Us. We conducted a cross\u2010sectional analysis combining survey and electronic health record data to estimate the prevalence of CVD upon enrollment in underrepresented groups defined by race, ethnicity, age (&gt;75\u00a0years), disability (not able to carry out everyday physical activities), sexual orientation and gender identity lesbian, gay, bisexual, transgender, queer, intersex, and asexual (LGBTQIA+), income (annual household income &lt;$35\u00a0000 US dollars) and education (less than a high school degree). We used multivariate logistic regression to estimate the adjusted odds ratio (OR) and product terms to test for interaction. The latest All of Us data release includes 315\u00a0297 participants. Of these, 230\u00a0577 (73%) had information on CVD and 17\u00a0958 had CVD (overall prevalence, 7.8%; 95% CI, 7.7\u20137.9). Multivariate analyses adjusted by hypertension, hyperlipidemia, type 2 diabetes mellitus, body mass index, and smoking indicated that, compared with White participants, Black participants had a higher adjusted odds of CVD (OR, 1.21; 95% CI, 1.16\u20131.27). Higher adjusted odds of CVD were also observed in underrepresented groups defined by other factors, including age &gt;75\u00a0years (OR, 1.90; 95% CI, 1.81\u20131.99), disability (OR, 1.60; 95% CI, 1.53\u20131.68), and income &lt;$35\u00a0000 US dollars (OR, 1.22; 95% CI, 1.17\u20131.27). Sex significantly modified the odds of CVD in several of the evaluated groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Among participants enrolled in All of Us, underrepresented groups defined based on race, ethnicity and other factors have a disproportionately high burden of CVD. The All of Us research program constitutes a powerful platform to accelerate research focused on individuals in underrepresented groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.121.021724","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T05:14:52Z","timestamp":1629868492000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Cardiovascular Health Disparities in Racial and Other Underrepresented Groups: Initial Results From the All of Us Research Program"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6497-5454","authenticated-orcid":false,"given":"Juli\u00e1n N.","family":"Acosta","sequence":"first","affiliation":[{"name":"Department of Neurology Yale School of Medicine New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9462-5022","authenticated-orcid":false,"given":"Audrey C.","family":"Leasure","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale School of Medicine New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron P.","family":"Both","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale School of Medicine New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6160-9221","authenticated-orcid":false,"given":"Natalia","family":"Szejko","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale School of Medicine New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy","family":"Brown","sequence":"additional","affiliation":[{"name":"John A. Burns School of Medicine University of Hawaii Honolulu HI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Torres\u2010Lopez","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale School of Medicine New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safa","family":"Abdelhakim","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale School of Medicine New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Schindler","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale School of Medicine New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9711-3340","authenticated-orcid":false,"given":"Nils","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale School of Medicine New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6898-1680","authenticated-orcid":false,"given":"Lauren","family":"Sansing","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale School of Medicine New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6450-0368","authenticated-orcid":false,"given":"Thomas M.","family":"Gill","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yale School of Medicine New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2003-5473","authenticated-orcid":false,"given":"Kevin N.","family":"Sheth","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale School of Medicine New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6407-0302","authenticated-orcid":false,"given":"Guido J.","family":"Falcone","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale School of Medicine New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000950"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.86a.18088"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2018.304883"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.18150"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.119.005597"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1809937"},{"key":"e_1_3_2_8_2","unstructured":"The All of Us Research Program Initial Protocol. National Institutes of Health (NIH)\u2014All of Us. Published August 11 2020. Available at: https:\/\/allofus.nih.gov\/news\u2010events\u2010and\u2010media\/announcements\/all\u2010us\u2010research\u2010program\u2010initial\u2010protocol Accessed November 18 2020."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1510502113"},{"key":"e_1_3_2_10_2","unstructured":"Roumie CL Shirey\u2010Rice J & Kripalani S MidSouth CDRN\u2014Coronary Heart Disease Algorithm. PheKB. 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