{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T06:39:42Z","timestamp":1778222382657,"version":"3.51.4"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,11,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Sudden cardiac arrest (SCA) may be caused by an acute and reversible myocardial injury, a chronic and irreversible myocardial damage, or a primary ventricular arrhythmia. Cardiac magnetic resonance imaging may identify myocardial edema (ME), which denotes acute and reversible myocardial damage. We evaluated the arrhythmic outcome of SCA survivors during follow\u2010up and tested the prognostic role of ME.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We included a consecutive series of 101 (71% men, median age 47\u00a0years) SCA survivors from 9 collaborative centers who underwent early (&lt;1\u00a0month) cardiac magnetic resonance imaging and received an implantable cardioverter\u2010defibrillator (ICD). On T2\u2010weighted sequences, ME was found in 18 of 101 (18%) patients. According to cardiac magnetic resonance imaging findings, the arrhythmic SCA was ascribed to acute myocardial injury (either ischemic [n=10] or inflammatory [n=8]), to chronic structural heart diseases (ischemic heart disease [n=11], cardiomyopathy [n=20], or other [n=23]), or to primarily arrhythmic syndrome (n=29). During a follow\u2010up of 47 months (28 to 67 months), 24 of 101 (24%) patients received an appropriate ICD intervention. ME was associated with a significantly higher survival free from both any ICD interventions (log\u2010rank=0.04) and ICD shocks (log\u2010rank=0.03) and remained an independent predictor of better arrhythmic outcome after adjustment for left ventricular ejection fraction and late gadolinium enhancement. The risk of appropriate ICD intervention was unrelated to the type of underlying heart disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">ME on early cardiac magnetic resonance imaging, which denotes an acute and transient arrhythmogenic substrate, predicted a favorable long\u2010term arrhythmic outcome of SCA survivors. These findings may have a substantial impact on future guidelines on the management of SCA survivors.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.021861","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T10:37:27Z","timestamp":1636972647000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Prognostic Role of Myocardial Edema as Evidenced by Early Cardiac Magnetic Resonance in Survivors of Out\u2010of\u2010Hospital Cardiac Arrest: A Multicenter Study"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3578-0583","authenticated-orcid":false,"given":"Alessandro","family":"Zorzi","sequence":"first","affiliation":[{"name":"Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5823-799X","authenticated-orcid":false,"given":"Giulia","family":"Mattesi","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Baldi","sequence":"additional","affiliation":[{"name":"Section of Cardiology Department of Molecular Medicine University of Pavia Italy"},{"name":"Cardiac Intensive Care Unit Arrhythmia and Electrophysiology and Experimental Cardiology Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1005-7612","authenticated-orcid":false,"given":"Mauro","family":"Toniolo","sequence":"additional","affiliation":[{"name":"Cardiothoracic Department University Hospital of Udine Udine Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5394-1312","authenticated-orcid":false,"given":"Federico","family":"Guerra","sequence":"additional","affiliation":[{"name":"Cardiology and Arrhythmology Clinic Marche Polytechnic UniversityUniversity Hospital \u201cOspedali Riuniti Umberto I \u2013 Lancisi \u2013 Salesi\u201d Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2088-8070","authenticated-orcid":false,"given":"Filippo Maria","family":"Cauti","sequence":"additional","affiliation":[{"name":"Arrhythmology Unit Cardiology Division S. Giovanni Calibita Hospital Isola Tiberina, Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7842-6202","authenticated-orcid":false,"given":"Alberto","family":"Cipriani","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"De Lazzari","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Muser","sequence":"additional","affiliation":[{"name":"Cardiothoracic Department University Hospital of Udine Udine Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7095-5732","authenticated-orcid":false,"given":"Giulia","family":"Stronati","sequence":"additional","affiliation":[{"name":"Cardiology and Arrhythmology Clinic Marche Polytechnic UniversityUniversity Hospital \u201cOspedali Riuniti Umberto I \u2013 Lancisi \u2013 Salesi\u201d Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5854-9782","authenticated-orcid":false,"given":"Lina","family":"Marcantoni","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Unit Cardiology Department Santa Maria Della Misericordia Hospital Rovigo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Manfrin","sequence":"additional","affiliation":[{"name":"Electrophysiology and Cardiac Pacing Unit San Maurizio Regional Hospital Bolzano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4752-8617","authenticated-orcid":false,"given":"Leonardo","family":"Cal\u00f2","sequence":"additional","affiliation":[{"name":"Cardiology Department Policlinico Casilino Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Lanzillo","sequence":"additional","affiliation":[{"name":"Cardiology Department Policlinico Casilino Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7645-6993","authenticated-orcid":false,"given":"Martina","family":"Perazzolo Marra","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9789-6661","authenticated-orcid":false,"given":"Simone","family":"Savastano","sequence":"additional","affiliation":[{"name":"Division of Cardiology Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1487-0392","authenticated-orcid":false,"given":"Domenico","family":"Corrado","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","first-page":"2986","article-title":"Sudden cardiac death: the pro\u2010arrhythmic interaction of an acute loading with an underlying substrate","volume":"38","author":"Sutherland GR","year":"2017","unstructured":"Sutherland GR. 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