{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T16:49:00Z","timestamp":1777740540776,"version":"3.51.4"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,12,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Associations of 1\u2010year change in functional performance measures with subsequent mobility loss and mortality in people with lower extremity peripheral artery disease are unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Six\u2010minute walk and 4\u2010meter walking velocity (usual and fastest pace) were measured at baseline and 1\u00a0year later in 612 people with peripheral artery disease (mean age 71\u00b19\u00a0years, 37% women). Participants were categorized into tertiles, based on 1\u2010year changes in walking measures. Cox proportional hazards models were used to examine associations between 1\u2010year change in each walking measure and subsequent mobility loss and mortality, respectively, adjusting for potential confounders. Compared with the best tertile, the worst tertile (ie, greatest decline) in 1\u2010year change in each performance measure was associated with higher rates of mobility loss: 6\u2010minute walk (Tertile 1 [T1] cumulative incidence rate [IR], 72\/160; Tertile 3 [T3] IR, 47\/160; hazard ratio [HR], 2.35; 95% CI, 1.47\u20133.74), usual\u2010paced 4\u2010meter walking velocity (T1 IR, 54\/162; T3 IR, 57\/162; HR, 2.21; 95% CI, 1.41\u20133.47), and fast\u2010paced 4\u2010meter walking velocity (T1 IR, 61\/162; T3 IR, 58\/162; HR, 1.81; 95% CI, 1.16\u20132.84). Compared with the best tertile, the worst tertiles in 1\u2010year change in 6\u2010minute walk (T1 IR, 66\/163; T3 IR, 54\/163; HR, 1.61; 95% CI, 1.07\u20132.43) and fast\u2010paced 4\u2010meter walking velocity (T1 IR, 63\/166; T3 IR, 44\/166; HR, 1.75; 95% CI, 1.16, 2.64) were associated with higher mortality.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In people with peripheral artery disease, greater 1\u2010year decline in 6\u2010minute walk or 4\u2010meter walking velocity may help identify people with peripheral artery disease at highest risk for mobility loss and mortality.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.021917","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T12:00:21Z","timestamp":1639656021000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["One\u2010Year Change in Walking Performance and Subsequent Mobility Loss and Mortality Rates in Peripheral Artery Disease: Longitudinal Data From the WALCS"],"prefix":"10.1161","volume":"10","author":[{"given":"Michael M.","family":"Hammond","sequence":"first","affiliation":[{"name":"Northwestern UniversityFeinberg School of Medicine Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Science Stanford University Palo Alto CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Northwestern UniversityFeinberg School of Medicine Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongxue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Northwestern UniversityFeinberg School of Medicine Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3724-7619","authenticated-orcid":false,"given":"Mary M.","family":"McDermott","sequence":"additional","affiliation":[{"name":"Northwestern UniversityFeinberg School of Medicine Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-136-12-200206180-00008"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.09.053"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.08.034"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2011.04.009"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.13.1599"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.4.453"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.12.034"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2007.01092.x"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.18.1986"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.842328"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2000.108640"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.04.044"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-013-0347-5"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.007002"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2017.03.438"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/49.2.M85"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(05)80040-0"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-1-200601030-00005"},{"key":"e_1_3_1_20_2","doi-asserted-by":"crossref","unstructured":"Guralnik JM Fried LP Simonsick EM Kasper JD Lafferty ME editors. 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