{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:04Z","timestamp":1787018104253,"version":"build-2736575974"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,10,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Elderly patients have a higher burden of comorbidities that influence clinical outcomes. We aimed to compare in\u2010hospital outcomes in patients \u226580\u00a0years old to younger patients, and to determine the factors associated with increased risk of major adverse events (MAE) after left atrial appendage closure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      The National Inpatient Sample was used to identify discharges after left atrial appendage closure between October 2015 and December 2018. The primary outcome was in\u2010hospital MAE defined as the composite of postprocedural bleeding, vascular and cardiac complications, acute kidney injury, stroke, and death. A total of 6779 hospitalizations were identified, of which, 2371 (35%) were \u226580\u00a0years old and 4408 (65%) were &lt;80\u00a0years old. Patients \u226580\u00a0years old experienced a higher rate of MAE compared with those aged &lt;80\u00a0years old (6.0% versus 4.6%,\n                      <jats:italic>P<\/jats:italic>\n                      =0.01), and this difference was driven by a numerically higher rate of cardiac complications (2.4% versus 1.8%,\n                      <jats:italic>P<\/jats:italic>\n                      =0.09) and death (0.3% versus 0.1%,\n                      <jats:italic>P<\/jats:italic>\n                      =0.05) among individuals \u226580\u00a0years old. In patients \u226580\u00a0years old, higher odds of in\u2010hospital MAE were observed in women (1.61\u2010fold), and those with preprocedural congestive heart failure (\u22482\u2010fold), diabetes (\u22481.5\u2010fold), renal disease (\u22482.6\u2010fold), anemia (\u22482.7\u2010fold), and dementia (\u22485\u2010fold). In patients &lt;80\u00a0years old, a higher risk of in\u2010hospital MAE was encountered among women (\u22481.4\u2010fold) and those with diabetes (\u22481.3\u2010fold), renal disease (\u22482.6\u2010fold), anemia (\u22482\u2010fold), and dyslipidemia (\u22481.2\u2010fold).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients \u226580\u00a0years old had higher rates of in\u2010hospital MAE compared with patients aged &lt;80\u00a0years old. Female sex and the presence of heart failure, diabetes, renal disease, and anemia were factors associated with in\u2010hospital MAE among both groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.121.021973","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T05:31:49Z","timestamp":1632461509000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Outcomes of Elderly Patients Undergoing Left Atrial Appendage Closure"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4773-6368","authenticated-orcid":false,"given":"Shubrandu S.","family":"Sanjoy","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics Schulich School of Medicine &amp; Dentistry Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Hee","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Schulich School of Medicine &amp; Dentistry Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert T.","family":"Sparrow","sequence":"additional","affiliation":[{"name":"London Health Science Centre Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8754-358X","authenticated-orcid":false,"given":"Hani","family":"Jneid","sequence":"additional","affiliation":[{"name":"Division of Cardiology Baylor School of Medicine and the Michael E DeBakey VAMC Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Dawn Abbott","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Warren Alpert Medical School of Brown University Providence RI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3438-8907","authenticated-orcid":false,"given":"Luis","family":"Nombela\u2010Franco","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute Hospital Cl\u00ednico San Carlos Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9758-0360","authenticated-orcid":false,"given":"Lorenzo","family":"Azzalini","sequence":"additional","affiliation":[{"name":"Division of Cardiology VCU Pauley Heart CenterVirginia Commonwealth University Richmond VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0037-0373","authenticated-orcid":false,"given":"David R.","family":"Holmes","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Chadi","family":"Alraies","sequence":"additional","affiliation":[{"name":"Detroit Medical Center Wayne State University Detroit MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9853-7591","authenticated-orcid":false,"given":"Islam Y.","family":"Elgendy","sequence":"additional","affiliation":[{"name":"Division of Cardiology Weill Cornell Medicine\u2010Qatar Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3042-6569","authenticated-orcid":false,"given":"Adrian","family":"Baranchuk","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology and Pacing Kingston General HospitalQueen's University Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9241-8890","authenticated-orcid":false,"given":"Mamas A.","family":"Mamas","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Research Group Centre for Prognosis Research Institute of Primary Care and Health Sciences Keele University Stoke\u2010on\u2010Trent United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1888-9429","authenticated-orcid":false,"given":"Rodrigo","family":"Bagur","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Schulich School of Medicine &amp; Dentistry Western University London Ontario Canada"},{"name":"London Health Science Centre Western University London Ontario Canada"},{"name":"Keele Cardiovascular Research Group Centre for Prognosis Research Institute of Primary Care and Health Sciences Keele University Stoke\u2010on\u2010Trent United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.010873"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.22.2864"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70264-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1584"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.17294\/2330-0698.1409"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euw295"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2017.06.002"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000665"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005008"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S171346"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.04.025"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJY15M01_06"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv730"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2018-313356"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2020-317741"},{"key":"e_1_3_2_17_2","volume-title":"Overview of the National (Nationwide) Inpatient Sample (NIS)","author":"Healthcare Cost Utilization Project","unstructured":"Healthcare Cost Utilization Project . 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