{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:29:05Z","timestamp":1790490545787,"version":"4.1.0"},"reference-count":52,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Anxiety is linked to elevated risk of cardiometabolic disease onset, but the underlying mechanisms remain unclear. We examined the prospective association of 2 anxiety facets, neuroticism and worry, with cardiometabolic risk (CMR) trajectories for 4 decades.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">The sample comprised 1561 men from an ongoing adult male cohort. In 1975, healthy men (mean age, 53 years [SD, 8.4 years]) completed the Eysenck Personality Inventory\u2010Short Form neuroticism scale and a Worries Scale. Seven CMR biomarkers were assessed every 3 to 5\u00a0years. The CMR score was the number of biomarkers categorized as high\u2010risk based on established cut points or medication use. Using mixed effects regression, we modeled CMR trajectories over age and evaluated their associations with neuroticism and worry. Using Cox regression, we examined associations of neuroticism and worry with risk of having \u22656 CMR high\u2010risk biomarkers through 2015. CMR increased at 0.8 markers per decade from age 33 to 65 years, at which point men had an average of 3.8 high\u2010risk markers, followed by a slower increase of 0.5 markers per decade. Higher neuroticism (B=0.08; 95% CI, 0.02\u20130.15) and worry levels (B=0.07; 95% CI, 0.001\u20130.13) were associated with elevated CMR across time, and with 13% (95% CI, 1.03\u20131.23) and 10% (95% CI, 1.01\u20131.20) greater risks, respectively, of having \u22656 high\u2010risk CMR markers, adjusting for potential confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">By middle adulthood, higher anxiety levels are associated with stable differences in CMR that are maintained into older ages. Anxious individuals may experience deteriorations in cardiometabolic health earlier in life and remain on a stable trajectory of heightened risk into older ages.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.121.022006","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T10:14:20Z","timestamp":1643019260000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Neuroticism, Worry, and Cardiometabolic Risk Trajectories: Findings From a 40\u2010Year Study of Men"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-8198","authenticated-orcid":false,"given":"Lewina O.","family":"Lee","sequence":"first","affiliation":[{"name":"National Center for Posttraumatic Stress Disorder at VA Boston Healthcare System Boston MA"},{"name":"Department of Psychiatry Boston University School of Medicine Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Grimm","sequence":"additional","affiliation":[{"name":"Department of Psychology Arizona State University Tempe AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Avron","family":"Spiro","sequence":"additional","affiliation":[{"name":"Massachusetts Veterans Epidemiology Research and Information Center VA Boston Healthcare System Boston MA"},{"name":"Department of Epidemiology Boston University School of Public Health Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura D.","family":"Kubzansky","sequence":"additional","affiliation":[{"name":"Department of Social and Behavioral Sciences Harvard T.H. Chan School of Public Health Boston MA"},{"name":"Lee Kum Sheung Center for Health and Happiness Harvard T.H. Chan School of Public Health Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.114.156554"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2016.11.004"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13606"},{"key":"e_1_3_1_5_2","first-page":"1121","article-title":"Association between anxiety and hypertension: a systematic review and meta\u2010analysis of epidemiological studies","volume":"11","author":"Pan Y","year":"2015","unstructured":"Pan Y, Wenpang C, Cheng Q, Dong W, An T, Yan J. Association between anxiety and hypertension: a systematic review and meta\u2010analysis of epidemiological studies. 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