{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T18:03:21Z","timestamp":1793815401863,"version":"4.6.1"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,1,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Myocardial injury in patients with COVID\u201019 is associated with increased mortality during index hospitalization; however, the relationship to long\u2010term sequelae of SARS\u2010CoV\u20102 is unknown. This study assessed the relationship between myocardial injury (high\u2010sensitivity cardiac troponin T level) during index hospitalization for COVID\u201019 and longer\u2010term outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">This is a prospective cohort of patients who were hospitalized at a single center between March and May 2020 with SARS\u2010CoV\u20102. Cardiac biomarkers were systematically collected. Outcomes were adjudicated and stratified on the basis of myocardial injury. The study cohort includes 483 patients who had high\u2010sensitivity cardiac troponin T data during their index hospitalization. During index hospitalization, 91 (18.8%) died, 70 (14.4%) had thrombotic complications, and 126 (25.6%) had cardiovascular complications. By 12\u00a0months, 107 (22.2%) died. During index hospitalization, 301 (62.3%) had cardiac injury (high\u2010sensitivity cardiac troponin T\u226714\u00a0ng\/L); these patients had 28.6%, 32.2%, and 33.2% mortality during index hospitalization, at 6 months, and at 12\u00a0months, respectively, compared with 4.1%, 4.9%, and 4.9% mortality for those with low\u2010level positive troponin and 0%, 0%, and 0% for those with undetectable troponin. Of 392 (81.2%) patients who survived the index hospitalization, 94 (24%) had at least 1 readmission within 12\u00a0months, of whom 61 (65%) had myocardial injury during the index hospitalization. Of 377 (96%) patients who were alive and had follow\u2010up after the index hospitalization, 211 (56%) patients had a documented, detailed clinical assessment at 6\u00a0months. A total of 78 of 211 (37.0%) had ongoing COVID\u201019\u2013related symptoms; 34 of 211 (16.1%) had neurocognitive decline, 8 of 211 (3.8%) had increased supplemental oxygen requirements, and 42 of 211 (19.9%) had worsening functional status.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Myocardial injury during index hospitalization for COVID\u201019 was associated with increased mortality and may predict who are more likely to have postacute sequelae of COVID\u201019. Among patients who survived their index hospitalization, the incremental mortality through 12\u00a0months was low, even among troponin\u2010positive patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.022010","type":"journal-article","created":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T11:33:45Z","timestamp":1640950425000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":39,"title":["Relationship Between Myocardial Injury During Index Hospitalization for SARS\u2010CoV\u20102 Infection and Longer\u2010Term Outcomes"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0177-2091","authenticated-orcid":false,"given":"Brittany","family":"Weber","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine, Heart and Vascular Center Brigham and Women\u2019s Hospital Harvard Medical School Boston 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