{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:11:54Z","timestamp":1793329914582,"version":"4.5.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,11,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Early generation drug\u2010eluting stents (DESs) showed a high grade of coronary endothelial dysfunction that was attributed to lack of stent reendothelialization. Endothelium\u2010dependent vasomotor response of current DESs and bioresorbable scaffolds (BRSs) remains unknown. This study sought to assess the device\u2010related endothelial function of current devices and to correlate neointima healing with endothelial function.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 206 patients from 4 randomized trials treated with the durable\u2010polymer everolimus\u2010eluting Xience (n=44), bioresorbable\u2010polymer sirolimus\u2010eluting Orsiro (n=35), polymer\u2010free biolimus\u2010eluting Biofreedom (n=24), bioactive endothelial\u2010progenitor cell\u2010capturing sirolimus\u2010eluting Combo DES (n=25), polymer\u2010based everolimus\u2010eluting Absorb (n=44), and Mg\u2010based sirolimus\u2010eluting Magmaris BRS (n=34) underwent endothelium\u2010dependent vasomotor tests and optical coherence tomography imaging, as per protocol, at follow\u2010up. Crude vasomotor responses of distal segments to low\u2010dose acetylcholine (10\n              <jats:sup>\u22126<\/jats:sup>\n              \u00a0mol\/L) were different between groups: bioresorbablepolymer DEShad the worst (\u22128.4%\u00b112.6%) and durable\u2010polymer DES had the most physiologic (\u22120.4%\u00b111.8%;\n              <jats:italic>P<\/jats:italic>\n              =0.014). High\u2010dose acetylcholine (10\n              <jats:sup>\u22124<\/jats:sup>\n              \u00a0mol\/L) showed similar responses between groups (ranging from \u221210.8%\u00b111.6% to \u221218.1%\u00b115.4%;\n              <jats:italic>P<\/jats:italic>\n              =0.229). Device healing was different between devices. Uncovered struts ranged from 6.3%\u00b17.1% (bioresorbable\u2010polymer DES) to 2.5%\u00b14.5% (bioactive DES;\n              <jats:italic>P<\/jats:italic>\n              =0.056). In multivariate models, endothelium\u2010dependent vasomotor response was associated with age, bioresorbable\u2010polymer DES, and angiographic lumen loss, but not with strut coverage nor plaque type. Endothelial dysfunction (defined as \u22654% vasoconstriction) was observed in 46.6% of patients with low\u2010dose and 68.9% with high\u2010dose acetylcholine, without differences between groups.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">At follow\u2010up, endothelial dysfunction was frequently observed in distal segments treated with current stents without remarkable differences between devices. Although neointima healing was different between devices, poor healing was not associated with endothelial dysfunction.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.022123","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T09:05:31Z","timestamp":1635930331000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Coronary Endothelium\u2010Dependent Vasomotor Function After Drug\u2010Eluting Stent and Bioresorbable Scaffold Implantation"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9731-4767","authenticated-orcid":false,"given":"Josep","family":"Gomez\u2010Lara","sequence":"first","affiliation":[{"name":"University Hospital of Bellvitge, Biomedical Research Institute of Bellvitge (IDIBELL) University of Barcelona, L\u2019 Hospitalet de Llobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4090-6646","authenticated-orcid":false,"given":"Loreto","family":"Oyarzabal","sequence":"additional","affiliation":[{"name":"University Hospital of Bellvitge, Biomedical Research Institute of Bellvitge (IDIBELL) University of Barcelona, L\u2019 Hospitalet de Llobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9567-3253","authenticated-orcid":false,"given":"Luis","family":"Ortega\u2010Paz","sequence":"additional","affiliation":[{"name":"Clinic Hospital of Barcelona August Pi i Sunyer Biomedical Research Institute (IDIBAPS) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5845-1435","authenticated-orcid":false,"given":"Salvatore","family":"Brugaletta","sequence":"additional","affiliation":[{"name":"Clinic Hospital of Barcelona August Pi i Sunyer Biomedical Research Institute (IDIBAPS) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6413-3502","authenticated-orcid":false,"given":"Rafael","family":"Romaguera","sequence":"additional","affiliation":[{"name":"University Hospital of Bellvitge, Biomedical Research Institute of Bellvitge (IDIBELL) University of Barcelona, L\u2019 Hospitalet de Llobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neus","family":"Salvatella","sequence":"additional","affiliation":[{"name":"Heart Disease Research Group Mar Hospital, Biomedical Research Institute of Mar Hospital (IMIM) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Roura","sequence":"additional","affiliation":[{"name":"University Hospital of Bellvitge, Biomedical Research Institute of Bellvitge (IDIBELL) University of Barcelona, L\u2019 Hospitalet de Llobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3676-0277","authenticated-orcid":false,"given":"Fernando","family":"Rivero","sequence":"additional","affiliation":[{"name":"University Hospital of La Princesa Health Resaerch Institute of La Princesa; CIBER\u2010CV Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Fuentes","sequence":"additional","affiliation":[{"name":"University Hospital of Bellvitge, Biomedical Research Institute of Bellvitge (IDIBELL) University of Barcelona, L\u2019 Hospitalet de Llobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7480-2511","authenticated-orcid":false,"given":"Fernando","family":"Alfonso","sequence":"additional","affiliation":[{"name":"University Hospital of La Princesa Health Resaerch Institute of La Princesa; CIBER\u2010CV Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imanol","family":"Otaegui","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department University Hospital of Vall Hebron Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1152-9594","authenticated-orcid":false,"given":"Bert","family":"Vandeloo","sequence":"additional","affiliation":[{"name":"University Hospital of Bellvitge, Biomedical Research Institute of Bellvitge (IDIBELL) University of Barcelona, L\u2019 Hospitalet de Llobregat Spain"},{"name":"Department of Cardiology Heart and Vascular Disease Center, Universty Hospital of Brussels Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Vaquerizo","sequence":"additional","affiliation":[{"name":"Heart Disease Research Group Mar Hospital, Biomedical Research Institute of Mar Hospital (IMIM) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2316-3705","authenticated-orcid":false,"given":"Manel","family":"Sabate","sequence":"additional","affiliation":[{"name":"Clinic Hospital of Barcelona August Pi i Sunyer Biomedical Research Institute (IDIBAPS) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8780-720X","authenticated-orcid":false,"given":"Josep","family":"Comin\u2010Colet","sequence":"additional","affiliation":[{"name":"University Hospital of Bellvitge, Biomedical Research Institute of Bellvitge (IDIBELL) University of Barcelona, L\u2019 Hospitalet de Llobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3249-3095","authenticated-orcid":false,"given":"Joan\u2010Antoni","family":"Gomez\u2010Hospital","sequence":"additional","affiliation":[{"name":"University Hospital of Bellvitge, Biomedical Research Institute of Bellvitge (IDIBELL) University of Barcelona, L\u2019 Hospitalet de Llobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht351"},{"key":"e_1_3_1_3_2","first-page":"C7","article-title":"Pathophysiology of vascular healing and stent mediated arterial injury","volume":"4","author":"Nakazawa G","year":"2008","unstructured":"Nakazawa G, Ladich E, Finn AV, Virmani R. 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