{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:24:23Z","timestamp":1790771063124,"version":"4.1.0"},"reference-count":71,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,7,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p xml:lang=\"en\">\n            Cangrelor is the only currently available intravenous platelet P2Y\n            <jats:sub>12<\/jats:sub>\n            receptor inhibitor. It is characterized by potent, predictable, and rapidly reversible antiplatelet effects. Cangrelor has been tested in the large CHAMPION (Cangrelor Versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition) program, where it was compared with different clopidogrel regimens, and it is currently indicated for use in patients with coronary artery disease undergoing percutaneous coronary intervention. However, the uptake of cangrelor use varies across the globe and may also include patients with profiles different from those enrolled in the registration trials. These observations underscore the need to fully examine the safety and efficacy of cangrelor in postregistration studies. There are several ongoing and planned studies evaluating the use of cangrelor in real\u2010world practice which will provide important insights to this extent. The current article provides a review on the pharmacology, clinical studies, contemporary use of cangrelor in real\u2010world practice, a description of ongoing studies, and futuristic insights on potential strategies on how to improve outcomes of patients undergoing percutaneous coronary intervention.\n          <\/jats:p>","DOI":"10.1161\/jaha.121.022125","type":"journal-article","created":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T13:07:18Z","timestamp":1625317638000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":85,"title":["Cangrelor: Clinical Data, Contemporary Use, and Future Perspectives"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8552-1272","authenticated-orcid":false,"given":"Leonardo","family":"De Luca","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Cardiosciences Azienda Ospedaliera San Camillo\u2010Forlanini Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6896-2941","authenticated-orcid":false,"given":"Philippe Gabriel","family":"Steg","sequence":"additional","affiliation":[{"name":"FACT (French Alliance for Cardiovascular Trials) and INSERM U\u20101148 AP\u2010HPH\u00f4pital BichatUniversit\u00e9 de Paris France"},{"name":"NHLI (National Heart and Lung Institute)Imperial CollegeICMS Royal Brompton Hospital London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1278-6245","authenticated-orcid":false,"given":"Deepak L.","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Heart and Vascular Center Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5156-7723","authenticated-orcid":false,"given":"Davide","family":"Capodanno","sequence":"additional","affiliation":[{"name":"Division of Cardiology A.O.U. Policlinico \"G. Rodolico\u2010San Marco\" University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8451-2131","authenticated-orcid":false,"given":"Dominick J.","family":"Angiolillo","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Florida College of Medicine Jacksonville FL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-09-0982"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-011-0667-5"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.09.057"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/2048872614560505"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.11.044"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.03.034"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.156"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904327"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706482"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.18"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.11.042"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.117.005528"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1586\/erc.09.101"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-012-0737-3"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1300815"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/1753944719893274"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/14779072.2019.1675513"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.031164"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.04.034"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.038317"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.08.017"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.2013.837701"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/0091270009344986"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/2048872617707960"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-015-1233-3"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2016.1133585"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.03020.x"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2007.05.020"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0000000000000158"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.10.004"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908628"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908629"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.2002"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.11.017"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.07.009"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcvp\/pvz002"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.187397"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.11.001"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.08.009"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.08.016"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2012.02.018"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.022"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy562"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61615-3"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.06.042"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.10.055"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv498"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-17-00723"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.06.046"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2016.1246714"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1688789"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.046928"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1721504"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0000000000000142"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-015-0445-3"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-18-00036"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.10.051"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-0410-z"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcvp\/pvaa107"},{"key":"e_1_3_2_61_2","unstructured":"Cangrelor United States full prescribing information [online]. https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2015\/204958lbl.pdf. Accessed January 21 2021."},{"key":"e_1_3_2_62_2","unstructured":"Kangrexal EPAR summary for the public [online]. https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/kengrexal. Accessed January 21 2021."},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa575"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx419"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1177\/0897190019872386"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2019.02.008"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v6.i6.415"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw619"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-303379"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010394"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.009449"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9072059"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.121.022125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:15:48Z","timestamp":1715598948000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.121.022125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,6]]},"references-count":71,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2021,7,6]]}},"alternative-id":["10.1161\/JAHA.121.022125"],"URL":"https:\/\/doi.org\/10.1161\/jaha.121.022125","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,6]]},"assertion":[{"value":"2021-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e022125"}}