{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:04:04Z","timestamp":1788350644883,"version":"build-2803163510"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,4,5]]},"abstract":"\n Background<\/jats:title>\n The mechanisms explaining the clinical benefits of ferric carboximaltose (FCM) in patients with heart failure, reduced or intermediate left ventricular ejection fraction, and iron deficiency remain not fully clarified. The Myocardial\u2010IRON trial showed short\u2010term cardiac magnetic resonance (CMR) changes suggesting myocardial iron repletion following administration of FCM but failed to find a significant increase in left ventricular ejection fraction in the whole sample. Conversely, the strain assessment could evaluate more specifically subtle changes in contractility. In this subanalysis, we aimed to evaluate the effect of FCM on the short\u2010term left and right ventricular CMR feature tracking derived strain.<\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n This is a post hoc subanalysis of the double\u2010blind, placebo\u2010controlled, randomized clinical trial that enrolled 53 ambulatory patients with heart failure and left ventricular ejection fraction <50%, and iron deficiency [Myocardial\u2010IRON trial (NCT03398681)]. Three\u2010dimensional left and 2\u2010dimensional right ventricular CMR tracking strain (longitudinal, circumferential, and radial) changes were evaluated before, 7 and 30\u00a0days after randomization using linear mixed\u2010effect analysis. The median (interquartile range) age of the sample was 73\u00a0years (65\u201378), and 40 (75.5%) were men. At baseline, there were no significant differences in CMR feature tracking strain parameters across both treatment arms. At 7 days, the only global 3\u2010dimensional left ventricular circumferential strain was significantly higher in the FCM treatment\u2010arm (difference: \u22121.6%,\n P<\/jats:italic>\n =0.001). At 30 days, and compared with placebo, global 3\u2010dimensional left ventricular strain parameters significantly improved in those allocated to FCM treatment\u2010arm [longitudinal (difference: \u22122.3%,\n P<\/jats:italic>\n <0.001), circumferential (difference: \u22122.5%,\n P<\/jats:italic>\n <0.001), and radial (difference: 4.2%,\n P<\/jats:italic>\n =0.002)]. Likewise, significant improvements in global right ventricular strain parameters were found in the active arm at 30 days (longitudinal [difference: \u22123.3%,\n P<\/jats:italic>\n =0.010], circumferential [difference: \u22124.5%,\n P<\/jats:italic>\n <0.001], and radial [difference: 4.5%,\n P<\/jats:italic>\n =0.027]).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n In patients with stable heart failure, left ventricular ejection fraction <50%, and iron deficiency, treatment with FCM was associated with short\u2010term improvements in left and right ventricular function assessed by CMR feature tracking derived strain parameters.<\/jats:p>\n <\/jats:sec>\n \n Registration<\/jats:title>\n \n URL:\n https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n ; Unique identifier: NCT03398681.\n <\/jats:p>\n 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