{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T17:41:18Z","timestamp":1772905278185,"version":"3.50.1"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,10,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">We have previously developed an intraprocedural automatic arrhythmia\u2010origin localization (AAOL) system to identify idiopathic ventricular arrhythmia origins in real time using a 3\u2010lead ECG. The objective was to assess the localization accuracy of ventricular tachycardia (VT) exit and premature ventricular contraction (PVC) origin sites in patients with structural heart disease using the AAOL system.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In retrospective and prospective case series studies, a total of 42 patients who underwent VT\/PVC ablation in the setting of structural heart disease were recruited at 2 different centers. The AAOL system combines 120\u2010ms QRS integrals of 3 leads (III, V2, V6) with pace mapping to predict VT exit\/PVC origin site and projects that site onto the patient\u2010specific electroanatomic mapping surface. VT exit\/PVC origin sites were clinically identified by activation mapping and\/or pace mapping. The localization error of the VT exit\/PVC origin site was assessed by the distance between the clinically identified site and the estimated site. In the retrospective study of 19 patients with structural heart disease, the AAOL system achieved a mean localization accuracy of 6.5\u00b12.6\u00a0mm for 25 induced VTs. In the prospective study with 23 patients, mean localization accuracy was 5.9\u00b12.6\u00a0mm for 26 VT exit and PVC origin sites. There was no difference in mean localization error in epicardial sites compared with endocardial sites using the AAOL system (6.0 versus 5.8\u00a0mm,\n              <jats:italic>P<\/jats:italic>\n              =0.895).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The AAOL system achieved accurate localization of VT exit\/PVC origin sites in patients with structural heart disease; its performance is superior to current systems, and thus, it promises to have potential clinical utility.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.022217","type":"journal-article","created":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T11:55:20Z","timestamp":1633521320000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Assessment of an ECG\u2010Based System for Localizing Ventricular Arrhythmias in Patients With Structural Heart Disease"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6082-8921","authenticated-orcid":false,"given":"Shijie","family":"Zhou","sequence":"first","affiliation":[{"name":"Alliance for Cardiovascular Diagnostic and Treatment Innovation Johns Hopkins University Baltimore MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2410-6892","authenticated-orcid":false,"given":"Amir","family":"AbdelWahab","sequence":"additional","affiliation":[{"name":"Department of Medicine Queen Elizabeth II Health Sciences Centre Halifax NS Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9602-2751","authenticated-orcid":false,"given":"John L.","family":"Sapp","sequence":"additional","affiliation":[{"name":"Department of Medicine Queen Elizabeth II Health Sciences Centre Halifax NS Canada"},{"name":"Department of Physiology and Biophysics Dalhousie University Halifax NS Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9918-0133","authenticated-orcid":false,"given":"Eric","family":"Sung","sequence":"additional","affiliation":[{"name":"Alliance for Cardiovascular Diagnostic and Treatment Innovation Johns Hopkins University Baltimore MD"},{"name":"Department of Biomedical Engineering Johns Hopkins University Baltimore MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7189-8434","authenticated-orcid":false,"given":"Konstantinos N.","family":"Aronis","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Section of Cardiac Electrophysiology Johns Hopkins Hospital Baltimore MD"},{"name":"Department of Biomedical Engineering Johns Hopkins University Baltimore MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James W.","family":"Warren","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics Dalhousie University Halifax NS Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"MacInnis","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics Dalhousie University Halifax NS Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8218-0206","authenticated-orcid":false,"given":"Rushil","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Section of Cardiac Electrophysiology Johns Hopkins Hospital Baltimore MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. Milan","family":"Hor\u00e1\u010dek","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Dalhousie University Halifax NS Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7427-6750","authenticated-orcid":false,"given":"Ronald","family":"Berger","sequence":"additional","affiliation":[{"name":"Alliance for Cardiovascular Diagnostic and Treatment Innovation Johns Hopkins University Baltimore MD"},{"name":"Division of Cardiology Department of Medicine Section of Cardiac Electrophysiology Johns Hopkins Hospital Baltimore MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2651-4352","authenticated-orcid":false,"given":"Harikrishna","family":"Tandri","sequence":"additional","affiliation":[{"name":"Alliance for Cardiovascular Diagnostic and Treatment Innovation Johns Hopkins University Baltimore MD"},{"name":"Division of Cardiology Department of Medicine Section of 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