{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:19:39Z","timestamp":1782433179530,"version":"3.54.5"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Controversy exists over whether sex has significant interaction with revascularization strategy for unprotected left main coronary artery disease. Higher mortality has been reported among women treated with percutaneous coronary intervention compared with coronary artery bypass grafting.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The DELTA (Drug\u2010Eluting Stents for Left Main Coronary Artery Disease) and DELTA\u20102 registries are international, multicentric registries evaluating the outcomes of subjects undergoing coronary revascularization for unprotected left main coronary artery disease. The primary outcome was a composite of death, myocardial infarction, or cerebrovascular accidents. The population consisted of 6253 patients, including 1689 (27%) women. Women were older and more likely to have diabetes and chronic kidney disease than men (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05). At a median follow\u2010up of 29\u00a0months (interquartile range 12\u201349), a significant interaction between sex and revascularization strategy was observed for the primary end point (p\n              <jats:sub>int<\/jats:sub>\n              =0.012) and all\u2010cause death (p\n              <jats:sub>int<\/jats:sub>\n              =0.037). Among women, compared with percutaneous coronary intervention, coronary artery bypass grafting was associated with lower risk of the primary end point (event rate 9.5% versus 15.3%; adjusted hazard ratio [AHR], 0.53; 95% CI, 0.35\u20130.79,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and all\u2010cause death (event rate 5.6% versus 11.7% AHR, 0.50; 95% CI, 0.30\u20130.82) and no significant differences were observed in men.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In women undergoing coronary revascularization for unprotected left main coronary artery disease, coronary artery bypass grafting was associated with lower risk of death, myocardial infarction, or cerebrovascular accidents whereas no significant differences between coronary artery bypass grafting and percutaneous coronary intervention were observed in men. Further dedicated studies are needed to determine the optimal revascularization strategy in women with unprotected left main coronary artery disease.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.022320","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T10:01:22Z","timestamp":1645524082000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Sex Differences in Outcomes After Percutaneous Coronary Intervention or Coronary Artery Bypass Graft for Left Main Disease: From the DELTA Registries"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6101-1403","authenticated-orcid":false,"given":"Francesco","family":"Moroni","sequence":"first","affiliation":[{"name":"Universit\u00e0 Vita\u2010Salute San Raffaele Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Beneduce","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennaro","family":"Giustino","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center New York City New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ieva","family":"Briede","sequence":"additional","affiliation":[{"name":"Latvian Centre of CardiologyPauls Stradins Clinical University Hospital Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Jung","family":"Park","sequence":"additional","affiliation":[{"name":"The Heart InstituteUniversity of Ulsan College of MedicineAsan Medical CenterUniversity of Ulsan Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8628-1410","authenticated-orcid":false,"given":"Joost","family":"Daemen","sequence":"additional","affiliation":[{"name":"Erasmus Medical CenterThoraxcenter Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Claude Morice","sequence":"additional","affiliation":[{"name":"Institut Hospitalier Jacques CartierRamsay G\u00e9n\u00e9rale de Sant\u00e9 Massy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunao","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit New Tokyo Hospital Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Meliga","sequence":"additional","affiliation":[{"name":"Department of Cardiology Mauriziano Hospital Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Cerrato","sequence":"additional","affiliation":[{"name":"San Luigi Gonzaga University HospitalOrbassano and Infermi Hospital, Rivoli Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj R","family":"Makkar","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Heart InstituteCedars\u2010Sinai Medical Center Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"D\u2019Ascenzo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Cardiology University of TurinCitt\u00e0 della Salute e della Scienza Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Lucarelli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University Rozzano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piera","family":"Capranzano","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ferrarotto Hospital University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Tchetche","sequence":"additional","affiliation":[{"name":"Clinique Pasteur Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0287-4193","authenticated-orcid":false,"given":"Christian","family":"Templin","sequence":"additional","affiliation":[{"name":"University Hospital of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Kirtane","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center and Cardiovascular Research Foundation New York City New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawel","family":"Buzman","sequence":"additional","affiliation":[{"name":"American Heart of Poland, Inc. 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