{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:22:05Z","timestamp":1790904125127,"version":"4.1.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,11,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Recent trial results support the efficacy of renal sympathetic denervation in lowering blood pressure (BP). While BP reduction in general is associated with a clinically meaningful reduction in cardiovascular events and mortality, such a relationship has not been described for patients undergoing renal sympathetic denervation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Clinical events were assessed in patients who underwent renal sympathetic denervation at our center using telephone\u2010 and clinical follow\u2010up, interviews with general practitioners, as well as review of hospital databases. Event rates were compared between BP responders (\u22655\u00a0mm\u00a0Hg 24\u2010hour ambulatory BP reduction) and non\u2010responders; 296 patients were included. Compared with baseline, 24\u2010hour systolic ambulatory BP was reduced by 8.3\u00b112.2\u00a0mm\u00a0Hg and diastolic BP by 4.8\u00b17.0\u00a0mm\u00a0Hg (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001 for both) after 3\u00a0months. One hundred eighty patients were classified as BP responders and 116 as non\u2010responders. During a median follow\u2010up time of 48\u00a0months, significantly less major adverse cardiovascular events (cardiovascular death, stroke, myocardial infarction, critical limb ischemia, renal failure) occurred in responders than in non\u2010responders (22 versus 23 events, hazard ratio [HR], 0.53 [95% CI, 0.28 to 0.97],\n              <jats:italic>P<\/jats:italic>\n              =0.041). This was consistent after adjustment for potential confounders as well as confirmed by propensity\u2010score matching. A proportional relationship was found between BP reduction after 3\u00a0months and frequency of major adverse cardiovascular events (HR, 0.75 [95% CI, 0.58 to 0.97] per 10\u00a0mm\u00a0Hg 24\u2010hour systolic ambulatory BP reduction).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Based on these observational data, blood pressure response to renal sympathetic denervation is associated with improved long\u2010term clinical outcome.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.022429","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T09:04:48Z","timestamp":1635498288000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["Comparison of Long\u2010Term Outcomes for Responders Versus Non\u2010Responders Following Renal Denervation in Resistant Hypertension"],"prefix":"10.1161","volume":"10","author":[{"given":"Karl","family":"Fengler","sequence":"first","affiliation":[{"name":"Department of Cardiology Heart Center Leipzig at University of Leipzig Germany"},{"name":"Leipzig Heart Institute Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Reimann","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart Center Leipzig at University of Leipzig Germany"},{"name":"Leipzig Heart Institute Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2901-8138","authenticated-orcid":false,"given":"Karl\u2010Philipp","family":"Rommel","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart Center Leipzig at University of Leipzig Germany"},{"name":"Leipzig Heart Institute Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8616-6751","authenticated-orcid":false,"given":"Karl\u2010Patrik","family":"Kresoja","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart Center Leipzig at University of Leipzig Germany"},{"name":"Leipzig Heart Institute Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Blazek","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart Center Leipzig at University of Leipzig Germany"},{"name":"Leipzig Heart Institute Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8175-276X","authenticated-orcid":false,"given":"Matthias","family":"Unterhuber","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart Center Leipzig at University of Leipzig Germany"},{"name":"Leipzig Heart Institute Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8082-6472","authenticated-orcid":false,"given":"Christian","family":"Besler","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart Center Leipzig at University of Leipzig Germany"},{"name":"Leipzig Heart Institute Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3939-2139","authenticated-orcid":false,"given":"Maximilian","family":"von Roeder","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart Center Leipzig at University of Leipzig Germany"},{"name":"Leipzig Heart Institute Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2976-2514","authenticated-orcid":false,"given":"Michael","family":"B\u00f6hm","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin III Kardiologie, Angiologie und Internistische IntensivmedizinSaarland University Hospital Homburg\/Saar Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Desch","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart Center Leipzig at University of Leipzig Germany"},{"name":"Leipzig Heart Institute Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0169-998X","authenticated-orcid":false,"given":"Holger","family":"Thiele","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart Center Leipzig at University of Leipzig Germany"},{"name":"Leipzig Heart Institute Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5993-4487","authenticated-orcid":false,"given":"Philipp","family":"Lurz","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart Center Leipzig at University of Leipzig Germany"},{"name":"Leipzig Heart Institute Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000065"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy339"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01225-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000447"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz118"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.04.036"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31082-1"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30554-7"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30951-6"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32281-X"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05283"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001301"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.005879"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV12I5A110"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.037654"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001739"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht151"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006196"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV12I2A43"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv192"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000752"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39553.670231.25"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.067"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.073"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.02.014"},{"key":"e_1_3_2_27_2","first-page":"93","article-title":"Reduced blood pressure\u2010lowering effect of catheter\u2010based renal denervation in patients with isolated systolic hypertension: data from symplicity HTN\u20103 and the global symplicity registry","volume":"38","author":"Mahfoud F","year":"2017","unstructured":"Mahfoud F, Bakris G, Bhatt DL, Esler M, Ewen S, Fahy M, Kandzari D, Kario K, Mancia G, Weber M, et al. Reduced blood pressure\u2010lowering effect of catheter\u2010based renal denervation in patients with isolated systolic hypertension: data from symplicity HTN\u20103 and the global symplicity registry. Eur Heart J. 2017;38:93\u2013100. https:\/\/doi.org\/10.1093\/eurheartj\/ehw325","journal-title":"Eur Heart J"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu441"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.5.1236"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.068064"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpt273"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/hy1201.097302"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199310000-00019"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.36.5.901"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03694"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.137273"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.79.4.733"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000751"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-020-01718-6"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.121.022429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:56:04Z","timestamp":1715601364000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.121.022429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,2]]},"references-count":38,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2021,11,2]]}},"alternative-id":["10.1161\/JAHA.121.022429"],"URL":"https:\/\/doi.org\/10.1161\/jaha.121.022429","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,2]]},"assertion":[{"value":"2021-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e022429"}}