{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:42:57Z","timestamp":1791348177705,"version":"4.3.1"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,11,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Heart failure (HF) is a known risk factor for ischemic stroke, but data regarding ischemic stroke during hospitalization for acute decompensated HF (ADHF) are limited.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We analyzed the data from a multicenter registry (Kyoto Congestive Heart Failure [KCHF] Registry) that enrolled 4056 consecutive patients with ADHF in Japan (mean age, 78\u00a0years; men, 2238 patients [55%]; acute coronary syndrome [ACS], 239 patients [5.9%]). We investigated the incidence and predictors of ischemic stroke during hospitalization for ADHF. During the hospitalization, 63 patients (1.6%) developed ischemic stroke. The median interval from admission to the onset of ischemic stroke was 7 [interquartile range: 2\u201314] days, and the most common underlying cause was cardioembolism (64%). Men (OR, 1.87; 95%CI, 1.11\u20133.24), ACS (OR, 2.31; 95%CI, 1.01\u20134.93), absence of prior HF hospitalization (OR, 2.21; 95%CI, 1.24\u20134.21), and high B\u2010type natriuretic peptide (BNP)\/N\u2010terminal proBNP (NT\u2010proBNP) levels (above the median) at admission (OR, 3.15; 95%CI, 1.84\u20135.60) were independently associated with ischemic stroke. In patients without ACS, the independent risk factors for ischemic stroke were fully consistent with those in the main analysis. Higher quartiles of BNP\/NT\u2010proBNP levels were significantly associated with higher incidence of ischemic stroke (\n              <jats:italic>P<\/jats:italic>\n              for trend, &lt;0.001). Patients with ischemic stroke showed higher in\u2010hospital mortality, longer length of hospital stay, and poorer functional status at discharge.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">During hospitalization for ADHF, 1.6% of the patients developed ischemic stroke. Men, ACS, absence of prior HF hospitalization, and high BNP\/NT\u2010proBNP levels at admission were independently associated with ischemic stroke.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.022525","type":"journal-article","created":{"date-parts":[[2021,10,23]],"date-time":"2021-10-23T11:30:13Z","timestamp":1634988613000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Ischemic Stroke in Acute Decompensated Heart Failure: From the KCHF Registry"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5029-1203","authenticated-orcid":false,"given":"Moritake","family":"Iguchi","sequence":"first","affiliation":[{"name":"Department of Cardiology National Hospital Organization Kyoto Medical Center Kyoto 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