{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:58:52Z","timestamp":1790567932118,"version":"4.1.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"23","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,12,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Anemia or low hemoglobin can increase the risk of stroke. However, the association between hemoglobin and outcomes after stroke is uncertain. In this study, we aimed to investigate the association between hemoglobin and clinical outcomes, including mortality, poor functional outcome, stroke recurrence, and composite vascular events at 1\u00a0year.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We included the patients diagnosed with acute ischemic stroke or transient ischemic attack from the Third China National Stroke Registry. We used the Cox model for mortality, stroke recurrence, and composite vascular events and the logistic model for the poor functional outcome to examine the relationship between hemoglobin and clinical outcomes. In addition, we used the restricted cubic spline to evaluate the nonlinear relationship. This study included 14\u00a0159 patients with acute ischemic stroke or transient ischemic attack. After adjusted for potential cofounders, both anemia and high hemoglobin were associated with the higher risk of mortality (hazard ratio [HR], 1.73; 95% CI, 1.39\u20132.15; HR, 2.71; 95% CI, 1.95\u20133.76) and poor functional outcome (odds ratio [OR], 1.36; 95% CI, 1.18\u20131.57; OR, 1.42; 95% CI, 1.07\u20131.87). High hemoglobin, but not anemia, increased the risk of stroke recurrence (HR, 1.37; 95% CI, 1.05\u20131.79) and composite vascular events (HR, 1.41; 95% CI, 1.08\u20131.83). There was a U\u2010shaped relationship between hemoglobin and mortality and poor functional outcome.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Abnormal hemoglobin was associated with a higher risk of all\u2010cause mortality, poor functional outcome, stroke recurrence, and composite vascular events. More well\u2010designed clinical studies are needed to confirm the relationship between hemoglobin and clinical outcomes after stroke.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.022547","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T19:13:53Z","timestamp":1638299633000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":52,"title":["Hemoglobin Concentration and Clinical Outcomes After Acute Ischemic Stroke or Transient Ischemic Attack"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4825-191X","authenticated-orcid":false,"given":"Runhua","family":"Zhang","sequence":"first","affiliation":[{"name":"National Center for Chronic and Noncommunicable Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China"},{"name":"Beijing Tiantan Hospital, Capital Medical University Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing Tiantan Hospital, Capital Medical University Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4351-2877","authenticated-orcid":false,"given":"Anxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Tiantan Hospital, Capital Medical University Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Beijing Tiantan Hospital, Capital Medical University Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Meng","sequence":"additional","affiliation":[{"name":"Beijing Tiantan Hospital, Capital Medical University Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maigeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"National Center for Chronic and Noncommunicable Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9976-2341","authenticated-orcid":false,"given":"Yongjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Tiantan Hospital, Capital Medical University Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7038-3444","authenticated-orcid":false,"given":"Gaifen","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Tiantan Hospital, Capital Medical University Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000506396"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30427-1"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2020-000457"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.013077"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2013.28.9.1316"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0203535"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12657"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.003019"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-10-22"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007723"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2019-000242"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.10.1407"},{"key":"e_1_3_1_14_2","first-page":"5","article-title":"Nutritional anaemias. Report of a WHO scientific group","volume":"405","year":"1968","unstructured":"Nutritional anaemias. Report of a WHO scientific group. World Health Organ Tech Rep Ser. 1968;405:5\u201337.","journal-title":"World Health Organ Tech Rep Ser"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.002672"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-018-1082-8"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.028058"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep26636"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/79.3.346"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000243794"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.5530130105"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S258381"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/hs0402.105339"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7352265"},{"key":"e_1_3_1_25_2","first-page":"Cd000103","article-title":"Haemodilution for acute ischaemic stroke","volume":"2014","author":"Chang TS","year":"2014","unstructured":"Chang TS, Jensen MB. 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Cochrane Database Syst Rev. 2014;2014:Cd000103. doi: 10.1002\/14651858.CD000103.pub2","journal-title":"Cochrane Database Syst Rev"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.121.022547","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T01:12:10Z","timestamp":1724289130000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.121.022547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,7]]},"references-count":24,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2021,12,7]]}},"alternative-id":["10.1161\/JAHA.121.022547"],"URL":"https:\/\/doi.org\/10.1161\/jaha.121.022547","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,7]]},"assertion":[{"value":"2021-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e022547"}}