{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:31:40Z","timestamp":1793017900010,"version":"4.5.0"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Assisted reproductive technology (ART) has emerged as a common treatment option for infertility, a problem that affects an estimated 48\u00a0million couples worldwide. Advancing maternal age with increasing prepregnancy cardiovascular risk factors, such as chronic hypertension, obesity, and diabetes, has raised concerns about pregnancy complications associated with ART. However, in\u2010hospital complications following pregnancies conceived by ART are poorly described.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              To assess the patient characteristics, obstetric outcomes, vascular complications and temporal trends of pregnancies conceived by ART, we analyzed hospital deliveries conceived with or without ART between January 1, 2008, and December 31, 2016, from the United States National Inpatient Sample database. We included 106\u00a0248 deliveries conceived with ART and 34\u00a0167\u00a0246 deliveries conceived without ART. Women who conceived with ART were older (35 versus 28\u00a0years;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) and had more comorbidities. ART\u2010conceived pregnancies were independently associated with vascular complications (acute kidney injury: adjusted odds ratio [aOR], 2.52; 95% CI 1.99\u20133.19; and arrhythmia: aOR, 1.65; 95% CI, 1.46\u20131.86), and adverse obstetric outcomes (placental abruption: aOR, 1.57; 95% CI, 1.41\u20131.74; cesarean delivery: aOR, 1.38; 95% CI, 1.33\u20131.43; and preterm birth: aOR, 1.26; 95% CI, 1.20\u20131.32), including in subgroups without cardiovascular disease risk factors or without multifetal pregnancies. Higher hospital charges ($18\u00a0705 versus $11\u00a0983;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) were incurred compared with women who conceived without ART.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Pregnancies conceived by ART have higher risks of adverse obstetric outcomes and vascular complications compared with spontaneous conception. Clinicians should have detailed discussions on the associated complications of ART in women during prepregnancy counseling.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.022658","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T10:06:06Z","timestamp":1645524366000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":34,"title":["In\u2010Hospital Complications in Pregnancies Conceived by Assisted Reproductive Technology"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0011-5636","authenticated-orcid":false,"given":"Pens\u00e9e","family":"Wu","sequence":"first","affiliation":[{"name":"Keele Cardiovascular Research Group School of Medicine Keele University Staffordshire United Kingdom"},{"name":"Academic Unit of Obstetrics and Gynaecology University Hospital of North Midlands Stoke\u2010on\u2010Trent United Kingdom"},{"name":"Department of Obstetrics and Gynecology National Cheng Kung University Hospital, College of MedicineNational Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7254-2077","authenticated-orcid":false,"given":"Garima V.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Ciccarone Center for the Prevention of Cardiovascular Disease Johns Hopkins University School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3493-1930","authenticated-orcid":false,"given":"Laxmi S.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine The Ohio State University Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn A.","family":"Chew\u2010Graham","sequence":"additional","affiliation":[{"name":"School of Medicine Keele University Staffordshire United Kingdom"},{"name":"National Institute for Health ResearchApplied Research CollaborationWest Midlands, Keele University Staffordshire United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8011-7094","authenticated-orcid":false,"given":"Gina P.","family":"Lundberg","sequence":"additional","affiliation":[{"name":"Division of Cardiology MedStar Heart and Vascular InstituteMedStar Washington Hospital CenterGeorgetown University Washington DC"},{"name":"Division of Cardiology Emory University School of Medicine Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara A.","family":"Nerenberg","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Obstetrics and Gynecology and Community Health Sciences University of Calgary Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Graham","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Alberta and Mazankowski Alberta Heart Institute Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6219-3379","authenticated-orcid":false,"given":"Lucy C.","family":"Chappell","sequence":"additional","affiliation":[{"name":"School of Life Course Sciences King\u2019s College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4433-2977","authenticated-orcid":false,"given":"Umesh T.","family":"Kadam","sequence":"additional","affiliation":[{"name":"Diabetes Research Centre University of Leicester Leicester United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4748-5335","authenticated-orcid":false,"given":"Kelvin P.","family":"Jordan","sequence":"additional","affiliation":[{"name":"School 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