{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:37:01Z","timestamp":1792654621528,"version":"4.5.0"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"23","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,12,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Systematic reviews have disclosed a lack of clinically relevant cardiac arrest animal models. The aim of this study was to develop a cardiac arrest model in pigs encompassing relevant cardiac arrest characteristics and clinically relevant post\u2010resuscitation care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">We used 2 methods of myocardial infarction in conjunction with cardiac arrest. One group (n=7) had a continuous coronary occlusion, while another group (n=11) underwent balloon\u2010deflation during arrest and resuscitation with re\u2010inflation after return of spontaneous circulation. A sham group was included (n=6). All groups underwent 48\u00a0hours of intensive care including 24\u00a0hours of targeted temperature management. Pigs underwent invasive hemodynamic monitoring. Left ventricular function was assessed by pressure\u2010volume measurements. The proportion of pigs with return of spontaneous circulation was 43% in the continuous infarction group and 64% in the deflation\u2010reinflation group. In the continuous infarction group 29% survived the entire protocol while 55% survived in the deflation\u2010reinflation group. Both cardiac arrest groups needed vasopressor and inotropic support and pressure\u2010volume measurements showed cardiac dysfunction. During rewarming, systemic vascular resistance decreased in both cardiac arrest groups. Median [25%;75%] troponin\u2010I 48\u00a0hours after return of spontaneous circulation, was 88\u00a0973\u00a0ng\/L [53\u00a0124;99\u00a0740] in the continuous infarction group, 19\u00a0661\u00a0ng\/L [10\u00a0871;23\u00a0209] in the deflation\u2010reinflation group, and 1973\u00a0ng\/L [1117;1995] in the sham group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">This article describes a cardiac arrest pig model with myocardial infarction, targeted temperature management, and clinically relevant post\u2010cardiac arrest care. We demonstrate 2 methods of inducing myocardial ischemia with cardiac arrest resulting in post\u2010cardiac arrest organ injury including cardiac dysfunction and cerebral injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.121.022679","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T07:34:50Z","timestamp":1638430490000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Cardiac Arrest in Pigs With 48\u00a0hours of Post\u2010Resuscitation Care Induced by 2 Methods of Myocardial Infarction: A Methodological Description"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5653-2992","authenticated-orcid":false,"given":"Lauge","family":"Vammen","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus 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