{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:12:44Z","timestamp":1791832364976,"version":"4.3.4"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,10,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Rupture of abdominal aortic aneurysm (rAAA) is associated with high case fatality rates, and risk of rupture increases with the AAA diameter. Heme oxygenase\u20101 (gene\n              <jats:italic>HMOX1<\/jats:italic>\n              , protein HO\u20101) is a stress\u2010induced protein and induction has protective effects in the vessel wall.\n              <jats:italic>\n                HMOX1\n                <jats:sup>\u2212\/\u2212<\/jats:sup>\n              <\/jats:italic>\n              mice are more susceptible to angiotensin II\u2010induced AAA formation, but the regulation in human nonruptured and ruptured AAA is only poorly understood. Our hypothesis proposed that HO\u20101 is reduced in AAA and lowering is inversely associated with the AAA diameter.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              AAA walls from patients undergoing elective open repair (eAAA) or surgery because of rupture (rAAA) were analyzed for aortic\n              <jats:italic>HMOX1<\/jats:italic>\n              \/HO\u20101 expression by quantitative real\u2010time polymerase chain reaction and Western blot. Aortas from patients with aortic occlusive disease served as controls.\n              <jats:italic>HMOX1<\/jats:italic>\n              \/HO\u20101 expression was 1.1\u2010 to 7.6\u2010fold upregulated in eAAA and rAAA. HO\u20101 expression was 3\u2010fold higher in eAAA specimen with a diameter &gt;84.4\u00a0mm, whereas HO\u20101 was not different in rAAA. Other variables that are known for associations with AAA and HO\u20101 induction were tested. In eAAA, HO\u20101 expression was negatively correlated with aortic collagen content and oxidative stress parameters H\n              <jats:sub>2<\/jats:sub>\n              O\n              <jats:sub>2<\/jats:sub>\n              release, oxidized proteins, and thiobarbituric acid reactive substances. Serum HO\u20101 concentrations were analyzed in patients with eAAA, and maximum values were found in an aortic diameter of 55 to 70\u00a0mm with no further increase &gt;70\u00a0mm, compared with &lt;55\u00a0mm.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Aortic HO\u20101 expression was increased in eAAA and rAAA. HO\u20101 increased with the severity of disease but was additionally connected to less oxidative stress and vasoprotective mechanisms.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.022747","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T09:47:14Z","timestamp":1633686434000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Induction of Heme Oxygenase\u20101 Is Linked to the Severity of Disease in Human Abdominal Aortic Aneurysm"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1490-6474","authenticated-orcid":false,"given":"Anja","family":"Hofmann","sequence":"first","affiliation":[{"name":"Division of Vascular and Endovascular Surgery Department of Visceral, Thoracic and Vascular Surgery University Hospital and Medical Faculty Carl Gustav Carus Technische Universit\u00e4t Dresden Dresden 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