{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:48:25Z","timestamp":1780447705943,"version":"3.54.1"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">In addition to primary neurodegenerative processes, vascular disorders, such as stroke, can lead to parkinsonism. However, some cardiovascular risk factors, such as smoking and elevated cholesterol levels, are associated with reduced risk of Parkinson disease. We examined the risk of Parkinson disease and secondary parkinsonism in 1\u2010year survivors of myocardial infarction (MI).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We conducted a nationwide population\u2010based matched cohort study using Danish medical registries from 1995 to 2016. We identified all patients with a first\u2010time MI diagnosis and sampled a sex\u2010, age\u2010, and calendar year\u2013matched general population comparison cohort without MI. Cox regression analysis was used to compute adjusted hazard ratios (aHRs) for Parkinson disease and secondary parkinsonism, controlled for matching factors and adjusted for relevant comorbidities and socioeconomic factors. We identified 181\u00a0994 patients with MI and 909\u00a0970 matched comparison cohort members (median age, 71\u00a0years; 62% men). After 21\u00a0years of follow\u2010up, the cumulative incidence was 0.9% for Parkinson disease and 0.1% for secondary parkinsonism in the MI cohort. Compared with the general population cohort, MI was associated with a decreased risk of Parkinson disease (aHR, 0.80; 95% CI, 0.73\u20130.87) and secondary parkinsonism (aHR, 0.72; 95% CI, 0.54\u20130.94).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">MI was associated with a 20% decreased risk of Parkinson disease and 28% decreased risk of secondary parkinsonism. Reduced risk may reflect an inverse relationship between cardiovascular risk factors and Parkinson disease.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.022768","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T15:07:42Z","timestamp":1645024062000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Risk of Parkinson Disease and Secondary Parkinsonism in Myocardial Infarction Survivors"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1276-1419","authenticated-orcid":false,"given":"Jens","family":"Sundb\u00f8ll","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Cardiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szimonetta 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