{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:21:17Z","timestamp":1790785277236,"version":"4.1.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,2,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Natriuretic peptides are routinely quantified to diagnose heart failure (HF). Their concentrations are also elevated in atrial fibrillation (AF). To clarify their value in predicting future cardiovascular events, we measured natriuretic peptides in unselected patients with cardiovascular conditions and related their concentrations to AF and HF status and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Consecutive patients with cardiovascular conditions presenting to a large teaching hospital underwent clinical assessment, 7\u2010day ECG monitoring, and echocardiography to diagnose AF and HF. NT\u2010proBNP (N\u2010terminal pro\u2010B\u2010type natriuretic peptide) was centrally quantified. Based on a literature review, four NT\u2010proBNP groups were defined (&lt;300, 300\u2013999, 1000\u20131999, and \u22652000\u00a0pg\/mL). Clinical characteristics and NT\u2010proBNP concentrations were related to HF hospitalization or cardiovascular death. Follow\u2010up data were available in 1616 of 1621 patients (99.7%) and analysis performed at 2.5\u00a0years (median age, 70 [interquartile range, 60\u201378] years; 40% women). HF hospitalization or cardiovascular death increased from 36 of 488 (3.2\/100 person\u2010years) in patients with neither AF nor HF, to 55 of 354 (7.1\/100 person\u2010years) in patients with AF only, 92 of 369 (12.1\/100 person\u2010years) in patients with HF only, and 128 of 405 (17.7\/100 person\u2010years) in patients with AF plus HF (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). Higher NT\u2010proBNP concentrations predicted the outcome in patients with AF only (C\u2010statistic, 0.82; 95% CI, 0.77\u20130.86;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001) and in other phenotype groups (C\u2010statistic in AF plus HF, 0.66; [95% CI, 0.61\u20130.70];\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Elevated NT\u2010proBNP concentrations predict future HF events in patients with AF irrespective of the presence of HF, encouraging routine quantification of NT\u2010proBNP in the assessment of patients with AF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.121.022833","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T09:26:36Z","timestamp":1643880396000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":46,"title":["Interactions Between Atrial Fibrillation and Natriuretic Peptide in Predicting Heart Failure Hospitalization or Cardiovascular Death"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4708-7276","authenticated-orcid":false,"given":"Paul F.","family":"Brady","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular Sciences College of Medical and Dental Sciences University of Birmingham Birmingham UK"},{"name":"Department of Cardiology Sandwell and West Birmingham NHS Trust Birmingham UK"},{"name":"Department of Cardiology University Hospitals Birmingham NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6747-8813","authenticated-orcid":false,"given":"Winnie","family":"Chua","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences College of Medical and Dental Sciences University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frantisek","family":"Nehaj","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences College of Medical and Dental Sciences University of Birmingham Birmingham UK"},{"name":"Department of Cardiology Sandwell and West Birmingham NHS Trust Birmingham UK"},{"name":"Department of Cardiac Electrophysiology and Pacing National Cardiovascular Institute Bratislava Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5471-133X","authenticated-orcid":false,"given":"Derek L.","family":"Connolly","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences College of Medical and Dental Sciences University of Birmingham Birmingham UK"},{"name":"Department of Cardiology Sandwell and West Birmingham NHS Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5866-5940","authenticated-orcid":false,"given":"Alya","family":"Khashaba","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences College of Medical and Dental Sciences University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanish J. V.","family":"Purmah","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences College of Medical and Dental Sciences University of Birmingham Birmingham UK"},{"name":"Department of Cardiology Sandwell and West Birmingham NHS Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6336-0327","authenticated-orcid":false,"given":"Muhammad J.","family":"Ul\u2010Qamar","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences College of Medical and Dental Sciences University of Birmingham Birmingham UK"},{"name":"Department of Cardiology Sandwell and West Birmingham NHS Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences College of Medical and Dental Sciences University of Birmingham Birmingham UK"},{"name":"Department of Cardiology 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