{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:02:59Z","timestamp":1791201779790,"version":"4.2.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,4,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Deoxycholic acid (DCA) is a secondary bile acid that may promote vascular calcification in experimental settings. Higher DCA levels were associated with prevalent coronary artery calcification (CAC) in a small group of individuals with advanced chronic kidney disease. Whether DCA levels are associated with CAC prevalence, incidence, and progression in a large and diverse population of individuals with chronic kidney disease stages 2 to 4 is unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">In the CRIC (Chronic Renal Insufficiency Cohort) study, we evaluated cross\u2010sectional (n=1057) and longitudinal (n=672) associations between fasting serum DCA levels and computed tomographic CAC using multivariable\u2010adjusted regression models. The mean age was 57\u00b112\u00a0years, 47% were women, and 41% were Black. At baseline, 64% had CAC (CAC score &gt;0 Agatston units). In cross\u2010sectional analyses, models adjusted for demographics and clinical factors showed no association between DCA levels and CAC &gt;0 compared with no CAC (prevalence ratio per 1\u2010SD higher log DCA, 1.08 [95% CI, 0.91\u20131.26). DCA was not associated with incident CAC (incidence per 1\u2010SD greater log DCA, 1.08 [95% CI, 0.85\u20131.39]) or CAC progression (risk for increase in \u2265100 and \u2265200 Agatston units per year per 1\u2010SD greater log DCA, 1.05 [95% CI, 0.84\u20131.31] and 1.26 [95% CI, 0.77\u20132.06], respectively).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Among CRIC study participants, DCA was not associated with prevalent, incident, or progression of CAC.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.022891","type":"journal-article","created":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T22:45:38Z","timestamp":1648161938000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Deoxycholic Acid and Coronary Artery Calcification in the Chronic Renal Insufficiency 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