{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T04:40:14Z","timestamp":1776314414934,"version":"3.50.1"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,1,18]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">It is unknown if stroke symptoms in the absence of a stroke diagnosis are a sign of subtle cardioembolic phenomena. The objective of this study was to examine associations between atrial fibrillation (AF) and stroke symptoms among adults with no clinical history of stroke or transient ischemic attack (TIA).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We evaluated associations between AF and self\u2010reported stroke symptoms in the national, prospective REGARDS (Reasons for Geographic and Racial Differences in Stroke) cohort. We conducted cross\u2010sectional (n=27\u00a0135) and longitudinal (n=21\u00a0932) analyses over 8\u00a0years of follow\u2010up of REGARDS participants without stroke\/transient ischemic attack and stratified by anticoagulant or antiplatelet agent use. The mean age was 64.4 (SD\u00b19.4) years, 55.3% were women, and 40.8% were Black participants; 28.6% of participants with AF reported stroke symptoms. In the cross\u2010sectional analysis, comparing participants with and without AF, the risk of stroke symptoms was elevated for adults with AF taking neither anticoagulants nor antiplatelet agents (odds ratio [OR], 2.22; 95% CI, 1.89\u20132.59) or antiplatelet agents only (OR, 1.92; 95% CI, 1.61\u20132.29) but not for adults with AF taking anticoagulants (OR, 1.08; 95% CI, 0.71\u20131.65). In the longitudinal analysis, the risk of stroke symptoms was also elevated for adults with AF taking neither anticoagulants nor antiplatelet agents (hazard ratio [HR], 1.41; 95% CI, 1.21\u20131.66) or antiplatelet agents only (HR, 1.23; 95% CI, 1.04\u20131.46) but not for adults with AF taking anticoagulants (HR, 0.86; 95% CI, 0.62\u20131.18).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Stroke symptoms in the absence of a stroke diagnosis may represent subclinical cardioembolic phenomena or \u201cwhispering strokes.\u201d Future studies examining the benefit of stroke symptom screening may be warranted.<\/jats:p>\n          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