{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:36:22Z","timestamp":1790516182041,"version":"4.1.0"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,3,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Patients who undergo percutaneous coronary intervention (PCI) are at increased risk for recurrent cardiovascular events despite aggressive medical therapy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This post hoc analysis focused on the subset of patients with prior PCI enrolled in REDUCE\u2010IT (Reduction of Cardiovascular Events With Icosapent Ethyl\u2013Intervention Trial), a multicenter, randomized, double\u2010blind, placebo\u2010controlled trial of icosapent ethyl versus placebo. Icosapent ethyl was added to statins in patients with low\u2010density lipoprotein cholesterol &lt;100\u00a0mg\/dL and fasting triglycerides 135\u2013499\u00a0mg\/dL. The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, coronary revascularization, or unstable angina requiring hospitalization. There were 8179 patients randomized in REDUCE\u2010IT followed for a median of 4.9\u00a0years, and 3408 (41.7%) of them had a prior PCI with a median follow\u2010up of 4.8\u00a0years. These patients were randomized a median of 2.9\u00a0years (11\u00a0days to 30.7\u00a0years) after PCI. Among patients treated with icosapent ethyl versus placebo, there was a 34% reduction in the primary composite end point (hazard ratio [HR], 0.66; 95% CI, 0.58\u20130.76;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001; number needed to treat\n              <jats:sup>4.8 years<\/jats:sup>\n              =12) and a 34% reduction in the key secondary composite end point of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke (HR, 0.66; 95% CI, 0.56\u20130.79;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001; NNT\n              <jats:sup>4.8 years<\/jats:sup>\n              =19) versus placebo. Similarly, large reductions occurred in total coronary revascularizations and revascularization subtypes. There was also a 39% reduction in total events (rate ratio, 0.61; 95% CI, 0.52\u20130.72;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Among patients treated with statins with elevated triglycerides and a history of prior PCI, icosapent ethyl substantially reduced the risk of recurrent events during an average of ~5\u00a0years of follow\u2010up with a number needed to treat of only 12.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT01492361.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.022937","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T10:07:08Z","timestamp":1646820428000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["Treatment With Icosapent Ethyl to Reduce Ischemic Events in Patients With Prior Percutaneous Coronary Intervention: Insights From REDUCE\u2010IT PCI"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1901-8628","authenticated-orcid":false,"given":"Benjamin E.","family":"Peterson","sequence":"first","affiliation":[{"name":"Brigham and Women\u2019s Hospital Heart and Vascular Center Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1278-6245","authenticated-orcid":false,"given":"Deepak L.","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital Heart and Vascular Center Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6896-2941","authenticated-orcid":false,"given":"Ph. Gabriel","family":"Steg","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de ParisAP\u2010HP (Assistance Publique\u2010H\u00f4pitaux de Paris)H\u00f4pital BichatFACT (French Alliance for Cardiovascular Trials)INSERM U\u20101148 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1679-2095","authenticated-orcid":false,"given":"Michael","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Maryland School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9807-4010","authenticated-orcid":false,"given":"Eliot A.","family":"Brinton","sequence":"additional","affiliation":[{"name":"Utah Lipid Center Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9926-2179","authenticated-orcid":false,"given":"Terry A.","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Department of Medicine Office of Health Promotion and Disease Prevention Emory University School of Medicine Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9302-4743","authenticated-orcid":false,"given":"Steven B.","family":"Ketchum","sequence":"additional","affiliation":[{"name":"Amarin Pharma, Inc. (Amarin) Bridgewater NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3714-6084","authenticated-orcid":false,"given":"Rebecca A.","family":"Juliano","sequence":"additional","affiliation":[{"name":"Amarin Pharma, Inc. (Amarin) Bridgewater NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7003-4925","authenticated-orcid":false,"given":"Lixia","family":"Jiao","sequence":"additional","affiliation":[{"name":"Amarin Pharma, Inc. (Amarin) Bridgewater NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4068-7778","authenticated-orcid":false,"suffix":"Jr.","given":"Ralph T.","family":"Doyle","sequence":"additional","affiliation":[{"name":"Amarin Pharma, Inc. (Amarin) Bridgewater NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Granowitz","sequence":"additional","affiliation":[{"name":"Amarin Pharma, Inc. (Amarin) Bridgewater NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Michael","family":"Gibson","sequence":"additional","affiliation":[{"name":"Baim Clinical Research Institute Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2309-8480","authenticated-orcid":false,"given":"Duane","family":"Pinto","sequence":"additional","affiliation":[{"name":"Baim Clinical Research Institute Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4110-7675","authenticated-orcid":false,"given":"Robert P.","family":"Giugliano","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital Heart and Vascular Center Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9616-1946","authenticated-orcid":false,"given":"Matthew J.","family":"Budoff","sequence":"additional","affiliation":[{"name":"David Geffen School of Medicine Lundquist Institute Torrance CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8200-8983","authenticated-orcid":false,"given":"Jean\u2010Claude","family":"Tardif","sequence":"additional","affiliation":[{"name":"Montreal Heart InstituteUniversit\u00e9 de Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4018-8533","authenticated-orcid":false,"given":"Subodh","family":"Verma","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery St Michael\u2019s HospitalUniversity of Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6432-1730","authenticated-orcid":false,"given":"Christie M.","family":"Ballantyne","sequence":"additional","affiliation":[{"name":"Department of Medicine Baylor College of MedicineCenter for Cardiovascular Disease PreventionMethodist DeBakey Heart and Vascular Center Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the REDUCE\u2010IT Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000757"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.034456"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy394"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000677"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.04.061"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13636-7"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2018.11.008"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.4396"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22692"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-020-01343-7"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1812792"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz778"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.08.007"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.06.043"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.044440"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz179"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.02.032"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcvp\/pvaa118"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.050276"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2021.08.003"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0000000000000800"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19970430)16:8<925::AID-SIM545>3.0.CO;2-2"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69416-6"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1410489"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1615664"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801174"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.038840"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.01.016"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz767"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23437"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2021.08.031"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000766"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.06.011"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.22258"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.052209"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.0824"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1811403"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2017.5205"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1804989"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203859"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.100997"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60527-3"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.103040"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2021.1954158"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.03.492"},{"key":"e_1_3_2_47_2","unstructured":"REDUCE\u2010IT EPA Trial Shows Association Between Higher EPA Levels Reduced CV Events \u2010 American College of Cardiology . Accessed November 23 2020. https:\/\/www.acc.org\/latest\u2010in\u2010cardiology\/articles\/2020\/03\/24\/16\/41\/mon\u20101045\u2010eicosapentaenoic\u2010acid\u2010levels\u2010in\u2010reduce\u2010it\u2010acc\u20102020."},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.313286"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2021.100106"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2021.102337"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/suaa114"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.09.005"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa652"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa184"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.121.022937","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:39:15Z","timestamp":1715600355000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.121.022937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,15]]},"references-count":53,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,3,15]]}},"alternative-id":["10.1161\/JAHA.121.022937"],"URL":"https:\/\/doi.org\/10.1161\/jaha.121.022937","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,15]]},"assertion":[{"value":"2021-10-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e022937"}}