{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:35:30Z","timestamp":1787506530413,"version":"build-2736575974"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"23","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,12,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">High triglycerides are associated with atherosclerotic cardiovascular disease (ASCVD) risks. Among patients with advanced chronic kidney disease (CKD), the association of elevated triglycerides with mortality is diminished and, thus, we investigated the relationship of triglycerides with ASCVD and non\u2010ASCVD hospitalizations across CKD stages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">The cohort comprised 2\u00a0963\u00a0176 veterans who received care in 2004 to 2006 (baseline) and were followed up to 2014. Using Cox models, we evaluated baseline and time\u2010varying triglycerides with time to ASCVD or non\u2010ASCVD hospitalizations, stratified by baseline CKD stage, and adjusted for demographics and baseline or time\u2010updated clinical characteristics. The cohort mean\u00b1SD age was 63\u00b114\u00a0years, with a baseline median (interquartile range) triglycerides level of 127 (87\u2013189) mg\/dL, and a quarter had prevalent CKD. There was a linear association between baseline triglycerides and ASCVD risk; however, the risk with high triglycerides \u2265240\u00a0mg\/dL attenuated with worsening CKD stages (reference: triglycerides 120 to &lt;160\u00a0mg\/dL). Baseline triglycerides were associated with a U\u2010shaped relationship for non\u2010ASCVD events in patients with CKD 3A to 3B. Patients with late\u2010stage CKD had lower to null relationships between baseline triglycerides and non\u2010ASCVD events. Time\u2010varying triglycerides associations with ASCVD were similar to baseline analyses. Yet, the time\u2010varying triglycerides relationship with non\u2010ASCVD events was inverse and linear, where elevated triglycerides were associated with lower risks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Associations of higher triglycerides with ASCVD and non\u2010ASCVD events declined across advancing CKD stages, where a lower to null risk was observed in patients with advanced CKD. Studies are needed to examine the impact of advanced CKD on triglycerides metabolism and its association with outcomes in this high\u2010risk population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.121.022988","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T05:06:01Z","timestamp":1635915961000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Risk of Atherosclerotic Cardiovascular Disease and Nonatherosclerotic Cardiovascular Disease Hospitalizations for Triglycerides Across Chronic Kidney Disease Stages Among 2.9\u00a0Million US Veterans"],"prefix":"10.1161","volume":"10","author":[{"given":"Melissa","family":"Soohoo","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension Harold Simmons Center for Kidney Disease Research and Epidemiology University of California Irvine Medical Center Orange CA"},{"name":"Nephrology Section Tibor Rubin Veterans Affairs Medical Center Long Beach CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3141-8720","authenticated-orcid":false,"given":"Leila","family":"Hashemi","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine Greater Los Angeles Healthcare System Los Angeles CA"},{"name":"David Geffen School of Medicine University of California Los Angeles Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jui\u2010Ting","family":"Hsiung","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension Harold Simmons Center for Kidney Disease Research and Epidemiology University of California Irvine Medical Center Orange CA"},{"name":"Nephrology Section Tibor Rubin Veterans Affairs Medical Center Long Beach CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Moradi","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension Harold Simmons Center for Kidney Disease Research and Epidemiology University of California Irvine Medical Center Orange CA"},{"name":"Nephrology Section Tibor Rubin Veterans Affairs Medical Center Long Beach CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9616-1946","authenticated-orcid":false,"given":"Matthew J.","family":"Budoff","sequence":"additional","affiliation":[{"name":"Division of Cardiology The Lundquist Institute for Biomedical Innovation at Harbor\u2010UCLA Medical Center Torrance CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csaba P.","family":"Kovesdy","sequence":"additional","affiliation":[{"name":"Nephrology Section Memphis Veterans Affairs Medical Center Memphis TN"},{"name":"Division of Nephrology University of Tennessee Health Science Center Memphis TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamyar","family":"Kalantar\u2010Zadeh","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension Harold Simmons Center for Kidney Disease Research and Epidemiology University of California Irvine Medical Center Orange CA"},{"name":"Nephrology Section Tibor Rubin Veterans Affairs Medical Center Long Beach CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1261-0098","authenticated-orcid":false,"given":"Elani","family":"Streja","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension Harold Simmons Center for Kidney Disease Research and Epidemiology University of California Irvine Medical Center Orange CA"},{"name":"Nephrology Section Tibor Rubin Veterans Affairs Medical Center Long Beach CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S52713"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-12-159"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.115.002104"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.78"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01450210"},{"key":"e_1_3_1_7_2","unstructured":"United States Renal Data System . 2016 USRDS annual data report: epidemiology of kidney disease in the United States. 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