{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:20:09Z","timestamp":1785529209303,"version":"3.56.0"},"reference-count":55,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,4,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Atmospheric changes in pollen concentration may affect human health by triggering various allergic processes. We sought to assess if changes in pollen concentrations were associated with different acute coronary syndrome (ACS) subtype presentations and short\u2010term clinical outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We analyzed data in consecutive patients presenting with ACS (unstable angina, non\u2013ST\u2010segment\u2013elevation myocardial infarction, and ST\u2010segment\u2013elevation myocardial infarction) treated with percutaneous coronary intervention between January 2014 and December 2017 and enrolled in the VCOR (Victorian Cardiac Outcomes Registry). Baseline characteristics were compared among patients exposed to different grass and total pollen concentrations. The primary outcome was occurrence of ACS subtypes and 30\u2010day major adverse cardiac and cerebrovascular events (composite of mortality, myocardial infarction, stent thrombosis, target vessel revascularization, or stroke). Of 15\u00a0379 patients, 7122 (46.3%) presented with ST\u2010segment\u2013elevation myocardial infarction, 6781 (44.1%) with non\u2013ST\u2010segment\u2013elevation myocardial infarction, and 1476 (9.6%) with unstable angina. The mean age was 62.5\u00a0years, with men comprising 76% of patients. No association was observed between daily or seasonal grass and total pollen concentrations with the frequency of ACS subtype presentation. However, grass and total pollen concentrations in the preceding days (2\u2010day average for grass pollen and 7\u2010day average for total pollen) correlated with in\u2010hospital mortality (odds ratio [OR], 2.17 [95% CI, 1.12\u20134.21];\n              <jats:italic>P<\/jats:italic>\n              =0.021 and OR, 2.78 [95% CI, 1.00\u20137.74];\n              <jats:italic>P<\/jats:italic>\n              =0.05), respectively, with a trend of 2\u2010day grass pollen for 30\u2010day major adverse cardiac and cerebrovascular events (OR, 1.50 [95% CI, 0.97\u20132.32];\n              <jats:italic>P<\/jats:italic>\n              =0.066).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Increased pollen concentrations were not associated with differential ACS subtype presentation but were significantly related to in\u2010hospital mortality following percutaneous coronary intervention, underscoring a potential biologic link between pollen exposure and clinical outcomes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.023036","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T10:52:18Z","timestamp":1647341538000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Temporal Changes in Pollen Concentration Predict Short\u2010Term Clinical Outcomes in Acute Coronary Syndromes"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4208-4586","authenticated-orcid":false,"given":"Omar","family":"Al\u2010Mukhtar","sequence":"first","affiliation":[{"name":"Department of Cardiology Western Health Melbourne Victoria 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T.","family":"Dinh","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela L.","family":"Brennan","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9173-3944","authenticated-orcid":false,"given":"Christopher","family":"Reid","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University Melbourne Victoria Australia"},{"name":"NHMRC Centre of Research Excellence in Cardiovascular Outcomes Improvement Curtin University Perth Western Australia 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Health Melbourne Victoria Australia"},{"name":"Department of Cardiology Alfred Health Melbourne Victoria Australia"},{"name":"Baker Heart and Diabetes Institute Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9684-888X","authenticated-orcid":false,"given":"William","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Western Health Melbourne Victoria Australia"},{"name":"Department of Medicine Western HealthMelbourne Medical SchoolUniversity of Melbourne Melbourne Victoria Australia"},{"name":"Department of Cardiology Alfred Health Melbourne Victoria Australia"},{"name":"Baker Heart and Diabetes Institute Melbourne Victoria 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