{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T02:46:45Z","timestamp":1780109205846,"version":"3.54.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,5,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The aim of this study was to establish prognostic hemodynamic parameters in patients with mitral stenosis secondary to mitral annular calcification.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A retrospective cohort of 105 patients undergoing transseptal catheterization for hemodynamic evaluation of mitral annular calcification\u2013related mitral stenosis between 2004 and 2020 was studied. Mitral valve gradient (MVG) and mitral valve area (MVA; calculated by the Gorlin formula) were measured using direct left atrial and left ventricular pressures. The median age of the patients was 70.3\u00a0years (58.4\u201376.7 years), and 53.3% were women. The median MVA was 1.7\u00a0cm\n              <jats:sup>2<\/jats:sup>\n              (1.3\u20132.3\u00a0cm\n              <jats:sup>2<\/jats:sup>\n              ) and MVG was 7.3\u00a0mm\u00a0Hg (5.3\u201310.3\u00a0mm\u00a0Hg); left ventricular end\u2010diastolic pressure was 17.6\u00b128.3\u00a0mm\u00a0Hg. During a median of 2.1\u00a0years (0.7\u20134.5\u00a0years), there were 63 deaths; 1\u2010 and 5\u2010year survival were 76% and 40%, respectively. There was no association between left ventricular end\u2010diastolic pressure and survival. After adjusting for age and comorbidities, both MVA (hazard ratio [HR], 0.50 per cm\n              <jats:sup>2<\/jats:sup>\n              ; 95% CI, 0.34\u20130.73) and MVG (HR, 1.1 per mm\u00a0Hg; 95% CI, 1.05\u20131.20) were independent predictors of death. Atrial fibrillation was also independently associated with mortality. When added to a combined model, MVA remained associated with death (HR, 0.51 per cm\n              <jats:sup>2<\/jats:sup>\n              ; 95% CI, 0.33\u20130.79) while MVG was not.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In patients with mitral annular calcification\u2013related mitral stenosis, survival was poor. MVA and MVG were independently associated with death, but MVA was a better predictor of outcomes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.023107","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T09:17:14Z","timestamp":1652692634000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Invasive Hemodynamic Predictors of Survival in Patients With Mitral Stenosis Secondary to Mitral Annular Calcification"],"prefix":"10.1161","volume":"11","author":[{"given":"Abdallah","family":"El Sabbagh","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic Jacksonville FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4651-9740","authenticated-orcid":false,"given":"Rick A.","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6082-5379","authenticated-orcid":false,"given":"Mackram F.","family":"Eleid","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorin V.","family":"Pislaru","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6800-3521","authenticated-orcid":false,"given":"Patricia A.","family":"Pellikka","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2044-4664","authenticated-orcid":false,"given":"Charanjit S.","family":"Rihal","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9151-8096","authenticated-orcid":false,"given":"Mayra","family":"Guerrero","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David O.","family":"Hodge","sequence":"additional","affiliation":[{"name":"Department of Health Science Research Mayo Clinic Jacksonville FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8864-8474","authenticated-orcid":false,"given":"William R.","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.08.872"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(52)90210-X"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000058168.26163.BC"},{"key":"e_1_3_1_5_2","first-page":"297","article-title":"Rupture of the posterior wall of the left heart at the atrio\u2010ventricular groove following mitral valve replacement","volume":"76","author":"Casarotto D","year":"1977","unstructured":"Casarotto D, Bortolotti U, Thiene G, Gallucci V, Cevese PG. 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