{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T01:01:25Z","timestamp":1781917285225,"version":"3.54.5"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Transposition of the great arteries (TGA) consists of about 3% of all congenital heart diseases and 20% of cyanotic congenital heart diseases. It is always accompanied by a series of other cardiac malformations that affect the surgical intervention strategy as well as prognosis. In this study, we comprehensively analyzed the phenotypes of the patients who had TGA with concordant atrioventricular and discordant ventriculoarterial connections and explored their association with prognosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We retrospectively reviewed 666 patients with a diagnosis of TGA with concordant atrioventricular and discordant ventriculoarterial connections in Fuwai Hospital from 1997 to 2019. Under the guidance of the Human Phenotype Ontology database, patients were classified into 3 clusters. The Kaplan\u2010Meier method was used to analyze the prognosis, and the Cox proportional regression model was used to investigate the risk factors. In this 666\u2010patient TGA cohort, the overall 5\u2010year survival rate was 94.70% (92.95%\u201396.49%). Three clusters with distinct phenotypes were obtained by the Human Phenotype Ontology database. Kaplan\u2010Meier analysis revealed a significant difference in freedom from reintervention among 3 clusters (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). To eliminate the effect of surgeries, we analyzed patients who only received an arterial switch operation and still found a significant difference in reintervention (\n              <jats:italic>P<\/jats:italic>\n              =0.019).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">We delineated a big cardiovascular phenotypic profile of an unprecedentedly large TGA cohort and successfully risk stratified them to reveal prognostic significance. Also, we reported the outcomes of a large TGA population in China.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.023181","type":"journal-article","created":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T03:10:45Z","timestamp":1641697845000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Deep Phenotypic Analysis for Transposition of the Great Arteries and Prognosis Implication"],"prefix":"10.1161","volume":"11","author":[{"given":"Huayan","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical SciencesPeking Union Medical College Beijing 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SciencesPeking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2988-9486","authenticated-orcid":false,"given":"Zhou","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical SciencesPeking Union Medical College Beijing 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