{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T13:31:44Z","timestamp":1781962304217,"version":"3.54.5"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,5,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">We investigated associations of childhood abuse with 4 cardiovascular disease risk factors in adulthood, and whether exposure to nurturing and household organization in childhood mitigated these associations.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">The CARDIA (Coronary Artery Risk Development in Young Adults) study (baseline examination, 1985\u20131986) was used to examine associations of childhood exposures (measured retrospectively at the year 15 examination) with incident obesity, type 2 diabetes, hypertension, and hyperlipidemia (assessed from baseline to year 30). Race\u2010 and sex\u2010stratified Cox proportional hazards models were used to examine associations of exposure to childhood abuse with incident cardiovascular disease risk factors. Interaction terms between exposure to abuse and exposure to nurturing relationship and household organization were included to test for effect modifications. Exposure to occasional\/frequent abuse (versus no abuse) was associated with incident type 2 diabetes among White men (hazard ratio [HR], 1.81; 95% CI, 1.06\u20133.08). Exposure to low versus no abuse was associated with incident hyperlipidemia among White men (HR, 1.35; 95% CI, 1.09\u20131.67) and White women (HR, 1.26; 95% CI, 1.01\u20131.56). Risks of incident hyperlipidemia were higher for White women who experienced abuse and lived in dysfunctional households (HR, 3.61; 95% CI, 1.62\u20138.05) or households with low levels of organization (HR, 2.05; 95% CI, 1.25\u20133.36) compared with White women who experienced abuse but lived in well\u2010organized households (HR, 0.66; 95% CI, 0.41\u20131.06). Similar patterns were seen for Black men who lived in dysfunctional households (HR, 3.62; 95% CI, 1.29\u201310.12) or households with low organization (HR, 2.01; 95% CI, 1.08\u20133.72).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">We identified race\u2010 and sex\u2010specific associations of childhood exposures with incident cardiovascular disease risk factors. The associations of household organization and dysfunction with cardiovascular disease risks merits further investigation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.023244","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T09:34:48Z","timestamp":1651052088000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Association of Exposure to Abuse, Nurture, and Household Organization in Childhood With 4 Cardiovascular Disease Risks Factors Among Participants in the CARDIA Study"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3496-0312","authenticated-orcid":false,"given":"Liliana","family":"Aguayo","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL"},{"name":"Mary Ann &amp; J. Milburn Smith Child Health Outreach, Research, and Evaluation CenterStanley Manne Children's Research InstituteAnn &amp; Robert H. Lurie Children's Hospital Chicago IL"},{"name":"Hubert Department of Global Health Rollins School of Public Health Emory University Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana A.","family":"Chirinos","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nia","family":"Heard\u2010Garris","sequence":"additional","affiliation":[{"name":"Mary Ann &amp; J. Milburn Smith Child Health Outreach, Research, and Evaluation CenterStanley Manne Children's Research InstituteAnn &amp; Robert H. Lurie Children's Hospital Chicago IL"},{"name":"Division of Advanced General Pediatrics and Primary Care Department of Pediatrics Ann &amp; Robert H. Lurie Children\u2019s Hospital of Chicago Chicago IL"},{"name":"Department of Pediatrics Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3808-2713","authenticated-orcid":false,"given":"Mandy","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew M.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL"},{"name":"Mary Ann &amp; J. Milburn Smith Child Health Outreach, Research, and Evaluation CenterStanley Manne Children's Research InstituteAnn &amp; Robert H. Lurie Children's Hospital Chicago IL"},{"name":"Division of Advanced General Pediatrics and Primary Care Department of Pediatrics Ann &amp; Robert H. Lurie Children\u2019s Hospital of Chicago Chicago IL"},{"name":"Department of Pediatrics Northwestern University Feinberg School of Medicine Chicago IL"},{"name":"Department of Medicine Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon Stein","family":"Merkin","sequence":"additional","affiliation":[{"name":"Division of Geriatrics Los Angeles Geffen School of MedicineUniversity of California Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Seeman","sequence":"additional","affiliation":[{"name":"Division of Geriatrics Los Angeles Geffen School of MedicineUniversity of California Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0063-6397","authenticated-orcid":false,"given":"Kiarri N.","family":"Kershaw","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-017-4691-z"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004158"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1403494817696600"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000536"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/1524839919882383"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1315458110"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(17)30118-4"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2020.106123"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2019.08.018"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-1554"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61706-7"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2403"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.3.394"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91163-0"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jech.2009.095109"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2019.3007"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40653-018-0217-9"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/tbm\/ibz042"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12662"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/DBP.0000000000000701"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1143921"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-018-1170-3"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2013.12.015"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000765"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-020-09411-z"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2019.112696"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2014.03.022"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(88)90080-7"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(87)90008-0"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(98)00017-8"},{"key":"e_1_3_1_32_2","unstructured":"Centers for Disease Control and Prevention . 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