{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T09:26:56Z","timestamp":1793179616599,"version":"4.5.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,4,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Stent thrombosis (ST) remains a significant medical issue. In particular, longer\u2010term mortality and clinical predictors after ST occurrence have yet to be elucidated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This was a multicenter, retrospective, observational study. A total of 187 definite ST cases from January 2008 to December 2017 were enrolled, and the long\u2010term clinical outcomes were investigated. The primary outcome measure was the cumulative mortality after ST occurrence. In addition, independent predictors of mortality were assessed. Among the stent types causing ST, bare\u2010metal stent, first\u2010generation drug\u2010eluting stent, second\u2010generation drug\u2010eluting stent, and third\u2010generation drug\u2010eluting stent comprised 31.0%, 19.3%, 36.9%, and 6.4% of cases, respectively. Median duration from stent implantation to ST was 680.5 (interquartile range, 33.8\u20132450.5) days. Cumulative mortality was 14.6%, 17.4%, 21.2%, 24.4%, and 33.8% at 1, 2, 3, 5 and 10\u00a0years, respectively. The cumulative mortality did not significantly differ by type of stent, and mortality of late ST was higher than that of early ST and very late ST; however, it did not reach statistical significance after the multivariate analysis. Independent predictors of mortality were hemodialysis (hazard ratio [HR], 7.80; 95% CI, 3.07\u201319.81;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), culprit lesions in the left main trunk (HR, 8.14; 95% CI, 1.71\u201338.75;\n              <jats:italic>P<\/jats:italic>\n              =0.008), culprit lesions in the left coronary artery (HR, 2.77; 95% CI, 1.10\u20136.96;\n              <jats:italic>P<\/jats:italic>\n              =0.030), and peak creatine kinase (HR, 1.017; 95% CI, 1.011\u20131.022;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The 10\u2010year cumulative mortality after ST reached 33.8%. Close follow\u2010up is thus mandatory for patients with ST, especially with hemodialysis, culprit lesions in the left main trunk and left coronary artery, and high peak creatine kinase.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.023276","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T13:25:57Z","timestamp":1649078757000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Long\u2010Term Outcomes and Clinical Predictors of Mortality Following Occurrence of Stent Thrombosis"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7505-0817","authenticated-orcid":false,"given":"Takayuki","family":"Ishihara","sequence":"first","affiliation":[{"name":"Kansai Rosai Hospital Cardiovascular Center Amagasaki 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atherectomy is useful to treat restenosis lesions due to crushing of a sirolimus\u2010eluting stent implanted in severely calcified lesions: experimental study and initial clinical experience","volume":"21","author":"Okamura A","year":"2009","unstructured":"Okamura A, Ito H, Fujii K. Rotational atherectomy is useful to treat restenosis lesions due to crushing of a sirolimus\u2010eluting stent implanted in severely calcified lesions: experimental study and initial clinical experience. J Invasive Cardiol. 2009;21:E191\u2013E196.","journal-title":"J Invasive Cardiol"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2018.08.019"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.121.023276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:30:26Z","timestamp":1715599826000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.121.023276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,5]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,4,5]]}},"alternative-id":["10.1161\/JAHA.121.023276"],"URL":"https:\/\/doi.org\/10.1161\/jaha.121.023276","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,5]]},"assertion":[{"value":"2021-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e023276"}}