{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T01:58:51Z","timestamp":1789869531881,"version":"4.0.1"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The relevance of sex and preimplant factors for clinical outcomes among patients with left ventricular assist devices intended for destination therapy is unclear.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) data (2006\u20102017) from 6771 men and 1690 women with left ventricular assist devices as destination therapy were analyzed to evaluate the contribution of preimplant clinical, demographic, and clinically judged psychosocial characteristics to time until death, heart transplant, device explant due to recovery, or complication\u2010related device replacement. Associations of sex with time until each competing outcome were evaluated using cumulative incidence functions and event\u2010specific Cox proportional hazards models. Women were younger, more likely to have nonischemic diagnoses, and reported less substance abuse but were more likely to be unmarried, not working for an income, overweight, and depressed than men. After 2\u00a0years, women had higher probabilities for recovery (3.7% versus 1.6%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and device replacement (12.1% versus 10%,\n              <jats:italic>P<\/jats:italic>\n              =0.019) than men but not for death and transplant (\n              <jats:italic>P<\/jats:italic>\n              &gt;0.12). The sex differences remained after controlling for covariates (adjusted hazard ratio [HR\n              <jats:sub>adj<\/jats:sub>\n              ] recovery, 1.85; 95% CI, 1.30\u20132.70;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001; HR\n              <jats:sub>adj<\/jats:sub>\n              device replacement, 1.22; 95% CI, 1.04\u20131.33;\n              <jats:italic>P<\/jats:italic>\n              =0.015). Female\u2010specific diagnoses (eg, postpartum heart failure) contributed to women\u2019s enhanced rate of recovery. Demographic and psychosocial factors were unrelated to women\u2019s increased event rates.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In destination therapy, women have higher rates of device replacement and recovery than men. The latter was partly explained by female\u2010specific diagnoses. Standardized assessments of psychosocial characteristics are needed to elucidate their association with sex differences in outcomes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.023294","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T10:03:25Z","timestamp":1645524205000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Sex Differences in Recovery and Device Replacement After Left Ventricular Assist Device Implantation as Destination Therapy"],"prefix":"10.1161","volume":"11","author":[{"given":"Lisa\u2010Marie","family":"Maukel","sequence":"first","affiliation":[{"name":"Health Psychology Trier University Trier Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerdi","family":"Weidner","sequence":"additional","affiliation":[{"name":"Biology, San Francisco State University San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Beyersmann","sequence":"additional","affiliation":[{"name":"Institute of Statistics Ulm University Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4600-2859","authenticated-orcid":false,"given":"Heike","family":"Spaderna","sequence":"additional","affiliation":[{"name":"Health Psychology Trier University Trier Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2019.12.005"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2017.07.005"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2020.04.015"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001288"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2017.06.016"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.111.963272"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2019.07.032"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.119.006082"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2019.01.008"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2019.04.017"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2019.05.014"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.116.003157"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.07.743"},{"issue":"703","key":"e_1_3_2_15_2","article-title":"INTERMACS analysis of stroke during support with continuous\u2010flow left ventricular assist devices: Risk factors and outcomes. 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