{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T22:08:53Z","timestamp":1771625333845,"version":"3.50.1"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,9,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Atrial fibrillation (AF) is associated with anatomical and electrical remodeling. Some patients with AF have concomitant sick sinus syndrome and may need permanent pacemaker (PPM) implantation. Association between catheter ablation of AF timing and need for PPM in sick sinus syndrome has not been assessed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We used pooled electronic health data to perform retrospective cross\u2010sectional analysis of 66, \u00a0595 patients with AF and sick sinus syndrome to assess the need of PPM implantation temporally, with AF performed divided into earlier within 5\u00a0years (group 1), 5 to 10\u00a0years (group 2), or beyond 10\u00a0years (group 3) of diagnosis. PPM implantation was lowest among those who had catheter ablation within 5\u00a0years of sick sinus syndrome diagnosis: group 1 versus group 2 (18.15% versus 27.21%) and group 1 versus group 3 (18.15% versus 27.22%). Interestingly, there was no difference in risk of PPM between group 2 and group 3 (27.21% versus 27.22%; odds ratio [OR], 1.00 [95% CI, 0.85\u20131.20]).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Even after controlling known risk factors that increase the need for pacemaker implantation, timing of AF ablation was the strongest predictor for need for PPM. Patients adjusted OR of PPM was lower if patients had catheter ablation within 5\u00a0years of diagnosis compared with later than 5\u00a0years (adjusted OR, 0.64 [95% CI, 0.59\u20130.70]).<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.023333","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T09:09:11Z","timestamp":1652173751000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Early Versus Late Catheter Ablation of Atrial Fibrillation and Risk of Permanent Pacemaker Implantation in Patients With Underlying Sinus Node Dysfunction"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7920-3668","authenticated-orcid":false,"given":"Muhammad Umer","family":"Butt","sequence":"first","affiliation":[{"name":"Department of Cardiology New York University Langone Health New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazli","family":"Okumus","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute MetroHealth Medical Center\/Case Western Reserve University Cleveland OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Jabri","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute MetroHealth Medical Center\/Case Western Reserve University Cleveland OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Thomas","sequence":"additional","affiliation":[{"name":"Health Education Campus Case Western Reserve University Cleveland OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8577-5654","authenticated-orcid":false,"given":"Yasir","family":"Tarabichi","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Critical Care, and Sleep Medicine MetroHealth Medical Center\/Case Western Reserve University Cleveland OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6252-2400","authenticated-orcid":false,"given":"Saima","family":"Karim","sequence":"additional","affiliation":[{"name":"Department of Cardiology New York University Langone Health New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1982.00340150171027"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2000.109652"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000090685.13169.07"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2002.00020.x"},{"key":"e_1_3_1_6_2","first-page":"30","article-title":"Sinus node dysfunction in atrial fibrillation: cause or effect?","volume":"1","author":"Kezerashvili A","year":"2008","unstructured":"Kezerashvili A, Krumerman AK, Fisher JD. 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