{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T17:17:09Z","timestamp":1763572629745,"version":"3.41.2"},"reference-count":55,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,3,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Myocardial dysfunction is a critical cause of post\u2010cardiac arrest hemodynamic instability and circulatory failure that may lead to early mortality after resuscitation. Trimetazidine is a metabolic agent that has been demonstrated to provide protective effects in myocardial ischemia. However, whether trimetazidine protects against postresuscitation myocardial dysfunction is unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Cardiopulmonary resuscitation was initiated after 8\u00a0minutes of untreated ventricular fibrillation in Sprague\u2010Dawley rats. Animals were randomized to 4 groups immediately after resuscitation (n=15\/group): (1) normothermia control (NTC); (2) targeted temperature management; (3) trimetazidine\u2010normothermia; (4) trimetazidine\u2010targeted temperature management. TMZ was administered at a single dose of 10\u00a0mg\/kg in rats with trimetazidine. The body temperature was maintained at 34.0\u00b0C for 2\u00a0hours and then rewarmed to 37.5\u00b0C in rats with targeted temperature management. Postresuscitation hemodynamics, 96\u2010hours survival, and pathological analysis were assessed. Heart tissues and blood samples of additional rats (n=6\/group) undergoing the same experimental procedure were collected to measure myocardial injury, inflammation and oxidative stress\u2010related biomarkers with ELISA\u2010based quantification assays. Compared with normothermia control, tumor necrosis factor\u2010\u03b1, and cardiac troponin\u2010I were significantly reduced, whereas the left ventricular ejection fraction and 96\u2010hours survival rates were significantly improved in the 3 experimental groups. Furthermore, inflammation and oxidative stress\u2010related biomarkers together with collagen volume fraction were significantly decreased in rats undergoing postresuscitation interventions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Trimetazidine significantly alleviates postresuscitation myocardial dysfunction and improves survival by decreasing oxidative stress and inflammation in a ventricular fibrillation rat model. A single dose of trimetazidine administrated immediately after resuscitation can effectively improve cardiac function, whether used alone or combined with targeted temperature management.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.023378","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T10:04:50Z","timestamp":1646820290000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Trimetazidine Alleviates Postresuscitation Myocardial Dysfunction and Improves 96\u2010Hour Survival in a Ventricular Fibrillation Rat Model"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0502-686X","authenticated-orcid":false,"given":"Jingru","family":"Li","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering and Imaging Medicine Army Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuantong","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics College of Pharmacy Army Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0983-1065","authenticated-orcid":false,"given":"Jianjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Imaging Medicine Army Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenxi","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Imaging Medicine Army Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bihua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Imaging Medicine Army Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6114-2382","authenticated-orcid":false,"given":"Yongqin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Imaging Medicine Army Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2015.01.003"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.110.001016"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182656976"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2014.05.021"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166324"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-011-9255-1"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001297"},{"key":"e_1_3_1_9_2","first-page":"B5054","article-title":"Oxidative and inflammatory biomarkers of ischemia and reperfusion injuries","volume":"62","author":"Halladin NL","year":"2015","unstructured":"Halladin NL. 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