{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T01:20:47Z","timestamp":1793496047172,"version":"4.5.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,4,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Left ventricular hypertrophy (LVH) is associated with increased mortality risk and rehospitalization after transcatheter aortic valve replacement among those with severe aortic stenosis. Whether cardiac troponin (cTnT) and NT\u2010proBNP (N\u2010terminal pro\u2010B\u2010type natriuretic peptide) risk stratify patients with aortic stenosis and without LVH is unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In a multicenter prospective registry of 923 patients with severe aortic stenosis undergoing transcatheter aortic valve replacement, we included 674 with core\u2010laboratory\u2010measured LV mass index, cTnT, and NT\u2010proBNP. LVH was defined by sex\u2010specific guideline cut\u2010offs and elevated biomarker levels were based on age and sex cut\u2010offs. Adjusted Cox proportional hazards models evaluated associations between LVH and biomarkers and all\u2010cause death out to 5\u00a0years. Elevated cTnT and NT\u2010proBNP were present in 82% and 86% of patients with moderate\/severe LVH, respectively, as compared with 66% and 69% of patients with no\/mild LVH, respectively (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001 for each). After adjustment, compared with no\/mild LVH, moderate\/severe LVH was associated with an increased hazard of mortality (adjusted hazard ratio [aHR], 1.34; 95% CI 1.01\u20131.77,\n              <jats:italic>P<\/jats:italic>\n              =0.043). cTnT and NT\u2010proBNP each risk stratified patients with moderate\/severe LVH (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05). In a model with both biomarkers and LVH included, elevated cTnT (aHR, 2.08; 95% CI 1.45\u20133.00,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and elevated NT\u2010proBNP (aHR, 1.46; 95% CI 1.00\u20132.11,\n              <jats:italic>P<\/jats:italic>\n              =0.049) were each associated with increased mortality risk, whereas moderate\/severe LVH was not (\n              <jats:italic>P<\/jats:italic>\n              =0.15).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Elevations in circulating cTnT and NT\u2010proBNP are more common as LVH becomes more pronounced but are also observed in those with no\/minimal LVH. As measures of maladaptive remodeling and cardiac injury, cTnT and NT\u2010proBNP predict post\u2010transcatheter aortic valve replacement mortality better than LV mass index. These findings may have important implications for risk stratification and treatment of patients with aortic stenosis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.023466","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T09:31:27Z","timestamp":1647595887000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":37,"title":["Left Ventricular Hypertrophy and Biomarkers of Cardiac Damage and Stress in Aortic Stenosis"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9958-0874","authenticated-orcid":false,"given":"Elliot J.","family":"Stein","sequence":"first","affiliation":[{"name":"Department of Medicine Vanderbilt University Medical Center Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1799-1368","authenticated-orcid":false,"given":"William F.","family":"Fearon","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Stanford Medical Center Palo Alto CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8013-8733","authenticated-orcid":false,"given":"Sammy","family":"Elmariah","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Massachusetts General Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9675-2607","authenticated-orcid":false,"given":"Juyong B.","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Stanford Medical Center Palo Alto CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0026-3391","authenticated-orcid":false,"given":"Samir","family":"Kapadia","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Cleveland Clinic Foundation Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4321-4538","authenticated-orcid":false,"given":"Dharam J.","family":"Kumbhani","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Texas Southwestern Medical Center Dallas TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1716-7574","authenticated-orcid":false,"given":"Linda","family":"Gillam","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Morristown Medical Center Morristown NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2973-3369","authenticated-orcid":false,"given":"Brian","family":"Whisenant","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Intermountain Heart Institute Murray 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