{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:20:02Z","timestamp":1789604402914,"version":"build-2803163510"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The extent of cardiac dysfunction post\u2010COVID\u201019 varies, and there is a lack of data on arrhythmic burden.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This was a combined multicenter prospective cohort study and cross\u2010sectional case\u2010control study. Cardiac function assessed by echocardiography in patients with COVID\u201019 3 to 4\u00a0months after hospital discharge was compared with matched controls. The 24\u2010hour ECGs were recorded in patients with COVID\u201019. A total of 204 patients with COVID\u201019 consented to participate (mean age, 58.5\u00a0years; 44% women), and 204 controls were included (mean age, 58.4\u00a0years; 44% women). Patients with COVID\u201019 had worse right ventricle free wall longitudinal strain (adjusted estimated mean difference, 1.5 percentage points; 95% CI, \u22122.6 to \u22120.5;\n              <jats:italic>P<\/jats:italic>\n              =0.005) and lower tricuspid annular plane systolic excursion (\u22120.10\u00a0cm; 95% CI, \u22120.14 to \u22120.05;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and cardiac index (\u22120.26\u00a0L\/min per m\n              <jats:sup>2<\/jats:sup>\n              ; 95% CI, \u22120.40 to \u22120.12;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), but slightly better left ventricle global strain (\u22120.8 percentage points; 95% CI, 0.2\u20131.3;\n              <jats:italic>P<\/jats:italic>\n              =0.008) compared with controls. Reduced diastolic function was twice as common compared with controls (60 [30%] versus 29 [15%], respectively; odds ratio, 2.4;\n              <jats:italic>P<\/jats:italic>\n              =0.001). Having dyspnea or fatigue were not associated with cardiac function. Right ventricle free wall longitudinal strain was worse after intensive care treatment. Arrhythmias were found in 27% of the patients, mainly premature ventricular contractions and nonsustained ventricular tachycardia (18% and 5%, respectively).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">At 3 months after hospital discharge with COVID\u201019, right ventricular function was mildly impaired, and diastolic dysfunction was twice as common compared with controls. There was little evidence for an association between cardiac function and intensive care treatment, dyspnea, or fatigue. Ventricular arrhythmias were common, but the clinical importance is unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\">http:\/\/clinicaltrials.gov<\/jats:ext-link>\n              . Unique Identifier: NCT04535154.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.023473","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T10:11:22Z","timestamp":1642673482000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":64,"title":["Cardiac Dysfunction and Arrhythmias 3\u00a0Months After Hospitalization for COVID\u201019"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3251-9494","authenticated-orcid":false,"given":"Charlotte B.","family":"Ingul","sequence":"first","affiliation":[{"name":"Department of Circulation and Medical Imaging Norwegian University of Science and Technology Trondheim Norway"},{"name":"The National Association for Heart, Lung diseases Hospital Gardermoen Jessheim 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