{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:33:26Z","timestamp":1791228806070,"version":"4.1.0"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,5,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Stent underexpansion has been known to be associated with worse outcomes. We sought to define optical coherence tomography assessed optimal stent expansion index (SEI), which associates with lower incidence of follow\u2010up major adverse cardiac events (MACEs).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 315 patients (involving 370 lesions) who underwent optical coherence tomography\u2013aided coronary stenting were retrospectively included. SEI was calculated separately for equal halves of each stented segment using minimum stent area\/mean reference lumen area ([proximal reference area+distal reference area]\/2). The smaller of the 2 was considered to be the SEI of that case. Follow\u2010up MACE was defined as a composite of all\u2010cause death, myocardial infarction, stent thrombosis, and target lesion revascularization. Average minimum stent area was 6.02 (interquartile range, 4.65\u20137.92) mm\n              <jats:sup>2<\/jats:sup>\n              , while SEI was 0.79 (interquartile range, 0.71\u20130.86). Forty\u2010seven (12.7%) incidences of MACE were recorded for 370 included lesions during a median follow\u2010up duration of 557 (interquartile range, 323\u20131103) days. Receiver operating characteristic curve analysis identified 0.85 as the best SEI cutoff (&lt;0.85) to predict follow\u2010up MACE (area under the curve, 0.60; sensitivity, 0.85; specificity, 0.34). MACE was observed in 40 of 260 (15.4%) lesions with SEI &lt;0.85 and in 7 of 110 (6.4%) lesions with SEI \u22650.85 (\n              <jats:italic>P<\/jats:italic>\n              =0.02). Least absolute shrinkage and selection operator regression identified SEI &lt;0.85 (odds ratio, 3.55; 95% CI, 1.40\u20139.05;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01) and coronary calcification (odds ratio, 2.47; 95% CI, 1.00\u20136.10;\n              <jats:italic>P<\/jats:italic>\n              =0.05) as independent predictors of follow\u2010up MACE.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The present study identified SEI &lt;0.85, associated with increased incidence of MACE, as the optimal cutoff in daily practice. Along with suboptimal SEI (&lt;0.85), coronary calcification was also found to be a significant predictor of follow\u2010up MACE.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.023493","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T09:48:55Z","timestamp":1650966535000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Stent Optimization Using Optical Coherence Tomography and Its Prognostic Implications After Percutaneous Coronary Intervention"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3917-1934","authenticated-orcid":false,"given":"Himanshu","family":"Rai","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Herz\u2010 und KreislauferkrankungenDeutsches Herzzentrum M\u00fcnchenTechnische Universit\u00e4t M\u00fcnchen Munich Germany"},{"name":"Cardiovascular Research Institute DublinMater Private Network Dublin Ireland"},{"name":"School of Pharmacy and Biomolecular Sciences RCSI University of Medicine and Health Sciences Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7601-8624","authenticated-orcid":false,"given":"Fiona","family":"Harzer","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Herz\u2010 und KreislauferkrankungenDeutsches Herzzentrum M\u00fcnchenTechnische Universit\u00e4t M\u00fcnchen Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7737-0374","authenticated-orcid":false,"given":"Tatsuhiko","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr KardiologieInselspital Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2708-4596","authenticated-orcid":false,"given":"Youssef S.","family":"Abdelwahed","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"},{"name":"DZHK (German Centre for Cardiovascular Research)partner site Berlin Bern Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Antu\u00f1a","sequence":"additional","affiliation":[{"name":"Hospital Universitario de La Princesa and Universidad Aut\u00f3noma de MadridCIBERCV Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Blachutzik","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Gie\u00dfen und Marburg Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Koppara","sequence":"additional","affiliation":[{"name":"Klinikum rechts der Isar Munich 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