{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:26:20Z","timestamp":1788337580970,"version":"build-2803163510"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,8,16]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Methamphetamine misuse affects 27\u00a0million people worldwide and is associated with cardiovascular disease (CVD); however, risk factors for CVD among users have not been well studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">We studied hospitalized patients in California, captured by the Healthcare Cost and Utilization Project database, between 2005 and 2011. We studied the association between methamphetamine use and CVD (pulmonary hypertension, heart failure, stroke, and myocardial infarction). Among 20\u2009249\u2009026 persons in the Healthcare Cost and Utilization Project, 66\u2009199 used methamphetamines (median follow\u2010up 4.58\u2009years). Those who used were more likely younger (33\u2009years versus 45\u2009years), male (63.3% versus 44.4%), smoked, misused alcohol, and had depression and anxiety compared with nonusers. Methamphetamine use was associated with the development of heart failure (hazard ratio [HR], 1.53 [95% CI, 1.45\u20131.62]) and pulmonary hypertension (HR, 1.42 [95% CI, 1.26\u20131.60]). Among users, male sex (HR, 1.73 [95% CI, 1.37\u20132.18]) was associated with myocardial infarction. Chronic kidney disease (HR, 2.38 [95% CI, 1.74\u20133.25]) and hypertension (HR, 2.26 [95% CI, 2.03\u20132.51]) were strong risk factors for CVD among users. When compared with nonuse, methamphetamine use was associated with a 32% significant increase in CVD, alcohol abuse with a 28% increase, and cocaine use with a 47% increase in CVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Methamphetamine use has a similar magnitude of risk of CVD compared with alcohol and cocaine. Prevention and treatment could be focused on those with chronic kidney disease, hypertension, and mental health disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.121.023663","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T05:14:26Z","timestamp":1659330866000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Clinical Correlates and Outcomes of Methamphetamine\u2010Associated Cardiovascular Diseases in Hospitalized Patients in California"],"prefix":"10.1161","volume":"11","author":[{"given":"Lara","family":"Curran","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Cardiology, University of California San Francisco San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3543-519X","authenticated-orcid":false,"given":"Gregory","family":"Nah","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology, University of California San Francisco San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5197-7696","authenticated-orcid":false,"given":"Gregory M.","family":"Marcus","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology, University of California San Francisco San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zian","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology, University of California San Francisco San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7103-2278","authenticated-orcid":false,"given":"Michael H.","family":"Crawford","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology, University of California San Francisco San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4531-9897","authenticated-orcid":false,"given":"Nisha I.","family":"Parikh","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology, University of California San Francisco San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","unstructured":"Crime UNOoDa . World Drug Report 2017. 2017."},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2012.11.016"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.312461"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2018.01.004"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2006.01.024"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.6.1657"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201705-0943OC"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2008.02231.x"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq043"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(08)70628-4"},{"key":"e_1_3_1_12_2","unstructured":"Administration SAaMHS . Key Substance Use and Mental Health Indicators in the United States: Results from the 2017 National Survey on Drug Use and Health (HHS Publication No. SMA 18\u20135068 NSDUH Series H\u201053). 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