{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:44:09Z","timestamp":1792010649039,"version":"4.4.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,4,5]]},"abstract":"<jats:sec xml:lang=\"en\"><jats:title>Background<\/jats:title><jats:p xml:lang=\"en\">Clinical outcomes of acute myocardial infarction complicated by cardiogenic shock remain poor with high in\u2010hospital mortality. Veno\u2010arterial extracorporeal membrane oxygenation (VA\u2010ECMO) has been widely used for patients with acute myocardial infarction complicated by cardiogenic shock refractory to conservative therapy, which is likely fatal without mechanical circulatory support. However, whether additional intra\u2010aortic balloon pumping (IABP) use during VA\u2010ECMO support improves clinical outcomes remains controversial. This study sought to investigate prognostic impact of the combined VA\u2010ECMO plus IABP treatment compared with VA\u2010ECMO alone.<\/jats:p><\/jats:sec><jats:sec xml:lang=\"en\"><jats:title>Methods and Results<\/jats:title><jats:p xml:lang=\"en\">From the nationwide Japanese administrative case\u2010mix Diagnostic Procedure Combination (DPC), the JROAD (Japanese Registry of All Cardiac and Vascular Diseases)\u2013DPC, we identified 3815 patients with acute myocardial infarction complicated by cardiogenic shock who underwent primary percutaneous coronary intervention and managed with VA\u2010ECMO. Of these, 2964 patients (77.7%) were managed with IABP (VA\u2010ECMO plus IABP), whereas 851 (22.3%) were managed without IABP (VA\u2010ECMO alone). We compared in\u2010hospital, 7\u2010day, and 30\u2010day mortality between the VA\u2010ECMO plus IABP versus the VA\u2010ECMO alone support. Patients managed with VA\u2010ECMO plus IABP demonstrated significantly lower in\u2010hospital, 7\u2010day, and 30\u2010day mortality than those managed with VA\u2010ECMO alone (adjusted odds ratios [95% CI] of 0.47 [95% CI, 0.38\u20130.59], 0.41 [95% CI, 0.33\u20130.51], and 0.30 [95% CI, 0.25\u20130.37], respectively). The findings were consistent in the propensity matching and inverse probability of treatment\u2010weighting models.<\/jats:p><\/jats:sec><jats:sec xml:lang=\"en\"><jats:title>Conclusions<\/jats:title><jats:p xml:lang=\"en\">This large\u2010scale, nationwide study demonstrated that the combination of VA\u2010ECMO plus IABP support was associated with significantly lower mortality compared with VA\u2010ECMO support alone in patients presenting with acute myocardial infarction complicated by cardiogenic shock who underwent primary percutaneous coronary intervention.<\/jats:p><\/jats:sec>","DOI":"10.1161\/jaha.121.023713","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T13:26:06Z","timestamp":1649078766000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":56,"title":["Outcomes of Venoarterial Extracorporeal Membrane Oxygenation Plus Intra\u2010Aortic Balloon Pumping for Treatment of Acute Myocardial Infarction Complicated by Cardiogenic Shock"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5503-4692","authenticated-orcid":false,"given":"Takeshi","family":"Nishi","sequence":"first","affiliation":[{"name":"Department of Cardiology Kawasaki Medical School Kurashiki Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School of Medical Sciences Kumamoto University Kumamoto City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Tsujita","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School of Medical Sciences Kumamoto University Kumamoto City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kawasaki Medical School Kurashiki Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Koto","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kawasaki Medical School Kurashiki Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2240-1510","authenticated-orcid":false,"given":"Michikazu","family":"Nakai","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1424-145X","authenticated-orcid":false,"given":"Yoko","family":"Sumita","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Iwanaga","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoaki","family":"Matoba","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Chiba University Graduate School of Medicine Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken\u2010Ichi","family":"Hirata","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Internal Medicine Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Hikichi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saga\u2010Ken Medical Centre Koseikan Saga 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