{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:55:35Z","timestamp":1793300135786,"version":"4.5.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,2,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Prognoses and long\u2010term cardiac function of patients with fulminant myocarditis have not been fully elucidated. Therefore, we clarified the prognoses and long\u2010term cardiac function according to required percutaneous mechanical circulatory support and histological findings among patients with fulminant myocarditis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We conducted a multicenter retrospective medical record review of 216 patients with fulminant myocarditis requiring percutaneous mechanical circulatory support. Sixty\u2010one patients were treated with intra\u2010aortic balloon pump or Impella alone, and 155 patients received veno\u2010arterial extracorporeal membrane oxygenation and were treated with or without intra\u2010aortic balloon pump or Impella. Histologically, 107 patients had lymphocytic myocarditis; 34, eosinophilic myocarditis; and 4, giant cell myocarditis. Freedom from composite end point (death, durable left ventricular assist device implantation, and heart transplantation) was 66% at 90\u00a0days, 62% at 1\u00a0year, and 57% at 6\u00a0years. Veno\u2010arterial extracorporeal membrane oxygenation use was associated with poor prognosis in the multivariable analysis (hazard ratio [HR], 5.27; 95% CI, 1.60\u201317.36). The eosinophilic myocarditis subgroup showed better prognosis (HR, 0.28; 95% CI, 0.10\u20130.80) compared with the lymphocytic myocarditis subgroup but not in the multivariable analysis. Ventricular tachycardia\/ventricular fibrillation rhythm at admission, high C\u2010reactive protein level, and no endomyocardial biopsy were also associated with poor prognosis. The left ventricular ejection fraction at 1\u00a0year was \u226450% in 16% of patients and was lower in patients with eosinophilic myocarditis (median: 57.9% [48.8\u201365.0%]) than in those with lymphocytic myocarditis (65.0% [58.6\u201368.7%]) (\n                      <jats:italic>P<\/jats:italic>\n                      =0.036).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients with fulminant myocarditis who received veno\u2010arterial extracorporeal membrane oxygenation had a poor prognosis. Long\u2010term cardiac function was impaired in some patients, especially those with eosinophilic myocarditis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.121.023719","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T06:28:23Z","timestamp":1644301703000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":49,"title":["Differences in Prognosis and Cardiac Function According to Required Percutaneous Mechanical Circulatory Support and Histological Findings in Patients With Fulminant Myocarditis: Insights From the CHANGE PUMP 2 Study"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6853-7574","authenticated-orcid":false,"given":"Toru","family":"Kondo","sequence":"first","affiliation":[{"name":"Department of Cardiology Nagoya University Graduate School of Medicine Nagoya 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