{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T19:17:05Z","timestamp":1768072625043,"version":"3.49.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,6,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">There are few studies on the association with Kawasaki disease in children and the family\u2019s history of cardiovascular disease (CVD). The aim of this study was to identify the association of increased risks for Kawasaki disease in children with a family history of CVD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Clinical data of children born in 2008 and 2009 (n=917\u00a0707) were obtained from the National Health Insurance Service and the National Health Screening Program for Infants and Children for this study. The cohort consisted of 495\u00a0215 participants (53.8%) who completed the family history questionnaire for children 54 to 60\u00a0months old. Family history of CVD included 5 medical conditions: hypertension, dyslipidemia, myocardial infarction, stroke, and diabetes. Kawasaki disease was defined using the disease code, intravenous immunoglobulin prescription, and use of antipyretics for more than 25\u00a0days. Severe Kawasaki disease was defined as diagnosis of accompanied cardiac\/coronary artery complications or intravenous immunoglobulin use \u22652 times. The incidence rate of Kawasaki disease was 124\/100\u00a0000\u00a0person\u2010years (95% CI, 117.5\u2013131.5) for children &lt;2\u00a0years old, 95\/100\u00a0000\u00a0person\u2010years (95% CI, 90.5\u2013100.4) in children 2 to 5\u00a0years old, and 14\/100\u00a0000\u00a0person\u2010years (95% CI, 12.6\u201315.6) in children &gt;5\u00a0years old. After propensity\u2010score matching, 829 participants with a family history of CVD were diagnosed as having Kawasaki disease (0.68% [95% CI, 0.63\u20130.72]), and 690 patients with Kawasaki disease (0.56% [95% CI, 0.52\u20130.61]) had no family history of CVD. The family history of CVD was associated with increased risk for Kawasaki disease (risk ratio, 1.20 [95% CI, 1.08\u20131.32]) but not for severe Kawasaki disease (risk ratio, 1.23 [95% CI, 0.92\u20131.65]).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In this nationwide propensity\u2010score matched study, those with a family history of CVD had a significantly greater risk of Kawasaki disease compared with those who had no family history of CVD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.023840","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T10:33:08Z","timestamp":1655202788000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Association of Familial History of Diabetes, Hypertension, Dyslipidemia, Stroke, or Myocardial Infarction With Risk of Kawasaki Disease"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6376-0427","authenticated-orcid":false,"given":"Ji Hee","family":"Kwak","sequence":"first","affiliation":[{"name":"Department of Pediatrics Kangbuk Samsung HospitalSungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8863-5729","authenticated-orcid":false,"given":"Eun Kyo","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kangnam Sacred Heart HospitalHallym University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4945-0753","authenticated-orcid":false,"given":"Ju Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kangdong Sacred Heart HospitalHallym University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0459-7655","authenticated-orcid":false,"given":"Hye Ryung","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Data Science Sejong University College of Software Convergence Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5632-5208","authenticated-orcid":false,"given":"Seung Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Data Science Sejong University College of Software Convergence Seoul Korea"},{"name":"Department of Precision Medicine Sungkyunkwan University School of Medicine Suwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9077-5779","authenticated-orcid":false,"given":"Man Yong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pediatrics CHA Bundang Medical Center CHA University School of Medicine Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","first-page":"681","article-title":"General pathology of Kawasaki disease. 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