{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T09:09:24Z","timestamp":1784365764957,"version":"3.55.0"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,3,21]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">GDF15 (growth differentiation factor 15) is a potent predictor of bleeding in people with cardiovascular disease. However, whether GDF15 is associated with bleeding in individuals without a history of cardiovascular disease is unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The study population was from the ARIC (Atherosclerosis Risk in Communities) study. We studied the association of GDF15 with hospitalized bleeding events among 9205 participants (1993\u20131995) without prior bleeding and cardiovascular disease (mean age 60\u2009years, 57% women, 21% Black). Plasma levels of GDF15 were measured in relative fluorescence units using DNA\u2010based aptamer technology. Bleeding was ascertained using discharge codes. We examined hazard ratios (HRs) of incident bleeding using Cox models and risk prediction with the addition of GDF15 to clinical predictors of bleeding. There were 1328 hospitalizations with bleeding during a median follow\u2010up of 22.5\u2009years. The majority (76.5%) were because of gastrointestinal bleeding. The absolute incidence rate of bleeding per 1000 person\u2010years was 11.64 in the highest quartile of GDF15 versus 5.22 in the lowest quartile. The highest versus lowest quartile of GDF15 demonstrated an adjusted HR of 2.00 (95% CI, 1.69\u20132.35) for total bleeding. The findings were consistent when we examined bleeding as the primary discharge diagnosis. The addition of GDF15 to clinical predictors of bleeding improved the C\u2010statistic by 0.006 (0.002\u20130.011) from 0.684 to 0.690,\n              <jats:italic>P<\/jats:italic>\n              =0.008.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Higher levels of GDF15 were associated with bleeding events and improved the risk prediction beyond clinical predictors in individuals without cardiovascular disease.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.023847","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T01:58:25Z","timestamp":1679018305000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Growth Differentiation Factor 15 and Risk of Bleeding Events: The Atherosclerosis Risk in Communities Study"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3780-7572","authenticated-orcid":false,"given":"Lena","family":"Mathews","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Welch Center Department of Epidemiology, Prevention and Clinical Research Johns Hopkins Bloomberg School of Public Health Baltimore MD"},{"name":"Division of Cardiology Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1515-1042","authenticated-orcid":false,"given":"Xiao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Welch Center Department of Epidemiology, Prevention and Clinical Research Johns Hopkins Bloomberg School of Public Health Baltimore 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