{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:22:19Z","timestamp":1792725739776,"version":"4.5.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,4,5]]},"abstract":"<jats:p xml:lang=\"en\">Advancement in the diagnosis and treatment of transthyretin amyloid cardiomyopathy has made great strides in recent years. Novel therapeutics for transthyretin amyloidosis such as tafamidis, patisiran, and inotersen have shown significant benefits in a not\u2010so\u2010rare disease but come with high listing price tags ranging from a quarter to more than a half million dollars per year. These costs create significant financial barriers for the majority of patients, especially those with existing Medicare insurance plans. Of 72 patients reviewed, 67% were Medicare beneficiaries. Financial assistance was explored for the majority, and 37 (51%) patients with Medicare Part D received financial assistance that reduced their copayments to $0. Only one\u2010third of our patients were able to afford these medications without any forms of financial assistance. Of these patients, 4 (6%) had the highest copayments ranging from $13\u00a0000 to $15\u00a0000 per year. To navigate the complexities of prescribing and affordability in amyloidosis, a multidisciplinary team including a dedicated clinical pharmacist is crucial in guaranteeing patients\u2019 success to secure these novel therapeutics. In this article, we discuss our experiences with prescribing, acquiring insurance authorizations, and financing these life\u2010saving medications based on patient\u2010specific insurance plans and socioeconomic status.<\/jats:p>","DOI":"10.1161\/jaha.121.023895","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T09:31:09Z","timestamp":1647595869000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Navigating the Complex Web of Prescribing Amyloidosis Therapeutics: A Primer"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8648-9251","authenticated-orcid":false,"given":"Hongya","family":"Chen","sequence":"first","affiliation":[{"name":"The Amyloidosis Center Knight Cardiovascular InstituteOregon Health &amp; Science University Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2249-1299","authenticated-orcid":false,"given":"Pranav","family":"Chandrashekar","sequence":"additional","affiliation":[{"name":"The Amyloidosis Center Knight Cardiovascular InstituteOregon Health &amp; Science University Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Fischer","sequence":"additional","affiliation":[{"name":"The Amyloidosis Center Knight Cardiovascular InstituteOregon Health &amp; Science University Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayna","family":"Carlson","sequence":"additional","affiliation":[{"name":"The Amyloidosis Center Knight Cardiovascular InstituteOregon Health &amp; Science University Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urja","family":"Narayan","sequence":"additional","affiliation":[{"name":"The Amyloidosis Center Knight Cardiovascular InstituteOregon Health &amp; Science University Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Chen","sequence":"additional","affiliation":[{"name":"The Amyloidosis Center Knight Cardiovascular InstituteOregon Health &amp; Science University Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6390-6526","authenticated-orcid":false,"given":"Ahmad","family":"Masri","sequence":"additional","affiliation":[{"name":"The Amyloidosis Center Knight Cardiovascular InstituteOregon Health &amp; Science University Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv338"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2013.11.004"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.11.033"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2020.04.007"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.04.003"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1805689"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1716793"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1716153"},{"key":"e_1_3_1_10_2","unstructured":"Lexicomp Online Lexi\u2010Drugs Lexicomp Online Lexi\u2010Drugs. 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