{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T06:31:13Z","timestamp":1780986673360,"version":"3.54.1"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,7,19]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Little is known about the cause of death (CoD) in patients with transposition of the great arteries palliated with a Mustard or Senning procedure. The aim was to describe the CoD for patients with the Mustard and Senning procedure during short\u2010 (&lt;10\u2009years), mid\u2010 (10\u201320\u2009years), and long\u2010term (&gt;20\u2009years) follow\u2010up after the operation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This is a retrospective, descriptive multicenter cohort study including all Nordic patients (Denmark, Finland, Norway, and Sweden) who underwent a Mustard or Senning procedure between 1967 and 2003. Patients who died within 30\u2009days after the index operation were excluded. Among 968 patients with Mustard\/Senning palliated transposition of the great arteries, 814 patients were eligible for the study, with a mean follow\u2010up of 33.6\u2009years. The estimated risk of all\u2010cause mortality reached 36.0% after 43\u2009years of follow\u2010up, and the risk of death was highest among male patients as compared with female patients (\n              <jats:italic>P<\/jats:italic>\n              =0.004). The most common CoD was sudden cardiac death (SCD), followed by heart failure\/heart transplantation accounting for 29% and 27%, respectively. During short\u2010, mid\u2010, and long\u2010term follow\u2010up, there was a change in CoD with SCD accounting for 23.7%, 46.6%, and 19.0% (\n              <jats:italic>P<\/jats:italic>\n              =0.002) and heart failure\/heart transplantation 18.6%, 22.4%, and 46.6% (\n              <jats:italic>P<\/jats:italic>\n              =0.0005), respectively.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Among patients corrected with Mustard or Senning transposition of the great arteries, the most common CoD is SCD followed by heart failure\/heart transplantation. The CoD changes as the patients age, with SCD as the most common cause in adolescence and heart failure as the dominant cause in adulthood. Furthermore, the risk of all\u2010cause mortality, SCD, and death attributable to heart failure or heart transplantation was increased in men &gt;10\u2009years after the Mustard\/Senning operation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.023921","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T11:16:32Z","timestamp":1657019792000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Cause\u2010Specific Mortality in Patients During Long\u2010Term Follow\u2010Up After Atrial Switch for Transposition of the Great Arteries"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4170-6416","authenticated-orcid":false,"given":"Annette Schophuus","family":"Jensen","sequence":"first","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8422-7127","authenticated-orcid":false,"given":"Troels H\u00f8jsgaard","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9116-8084","authenticated-orcid":false,"given":"Christina","family":"Christersson","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Cardiology Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7997-2878","authenticated-orcid":false,"given":"Edit","family":"Nagy","sequence":"additional","affiliation":[{"name":"Department of Medicine, Heart and Vascular Theme, Karolinska University Hospital Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0169-5137","authenticated-orcid":false,"given":"Juha","family":"Sinisalo","sequence":"additional","affiliation":[{"name":"Heart and Lung Center Helsinki University Central Hospital Helsinki Finland"},{"name":"Helsinki University Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3644-6998","authenticated-orcid":false,"given":"Eva","family":"Furen\u00e4s","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sahlgrenska Academy University of G\u00f6teborg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1913-6445","authenticated-orcid":false,"given":"Ola","family":"Gjesdal","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rikshospitalet Oslo University Hospital Oslo Norway"},{"name":"Faculty of Medicine University of Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sahlgrenska Academy University of G\u00f6teborg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Vejlstrup","sequence":"additional","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0976-6910","authenticated-orcid":false,"given":"Bengt","family":"Johansson","sequence":"additional","affiliation":[{"name":"Department of Surgery and Perioperative Sciences Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Hlebowicz","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lund University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0538-2656","authenticated-orcid":false,"given":"Gottfried","family":"Greve","sequence":"additional","affiliation":[{"name":"Department of Cardiology Haukeland University Hospital Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Dellborg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sahlgrenska Academy University of G\u00f6teborg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4787-8841","authenticated-orcid":false,"given":"Helge","family":"Skulstad","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rikshospitalet Oslo University Hospital Oslo Norway"},{"name":"Faculty of Medicine University of Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0394-5096","authenticated-orcid":false,"given":"Per","family":"Kvidal","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Cardiology Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eero","family":"Jokinen","sequence":"additional","affiliation":[{"name":"Heart and Lung Center Helsinki University Central Hospital Helsinki Finland"},{"name":"Helsinki University Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heikki","family":"Sairanen","sequence":"additional","affiliation":[{"name":"Heart and Lung Center Helsinki University Central Hospital Helsinki Finland"},{"name":"Helsinki University Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8651-4878","authenticated-orcid":false,"given":"Ulf","family":"Thil\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lund University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"S\u00f8ndergaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","first-page":"966","article-title":"Surgical correction of transposition of the great vessels","volume":"45","author":"Senning A","year":"1959","unstructured":"Senning A. Surgical correction of transposition of the great vessels. Surgery. 1959;45:966\u2013980.","journal-title":"Surgery"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)33339-2"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.40.2.237"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/tc.2000.6043"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.100.suppl_2.Ii-176"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.010770"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(94)70019-2"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2004.03.009"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.06.024"},{"key":"e_1_3_1_11_2","first-page":"III187","article-title":"Risk factors for arrhythmia and death after Mustard operation for simple transposition of the great arteries","volume":"84","author":"Gewillig M","year":"1991","unstructured":"Gewillig M, Cullen S, Mertens B, Lesaffre E, Deanfield J. Risk factors for arrhythmia and death after Mustard operation for simple transposition of the great arteries. Circulation. 1991;84:III187\u2013III192.","journal-title":"Circulation"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-6901"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006481"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(99)70329-6"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.80.2.170"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.029769"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12698"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu102"},{"key":"e_1_3_1_19_2","volume-title":"International Statistical Classification of Diseases and Related Health Problems","author":"ICD\u201010","year":"2011","unstructured":"ICD\u201010 . 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