{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T23:57:49Z","timestamp":1780099069301,"version":"3.54.0"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,3,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The prevalence and extent of subclinical large vessel vasculopathy is not well defined among people living with HIV. We aimed to evaluate associations between aortic root and ascending aortic sizes measured by 2\u2010dimensional transthoracic echocardiography and HIV serostatus, and to identify risk factors for larger aortic sizes among men with HIV, including levels of circulating inflammatory markers.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Using clinical and echocardiographic data from the MACS (Multicenter AIDS Cohort Study), adjusted multivariable linear and logistic regression was performed. Four segments of the proximal aorta were measured: aortic annulus, aortic root at the sinuses of Valsalva, sinotubular junction, and ascending aorta. HIV infection was associated with significantly larger aortic root (0.03\u00a0cm [95% CI, 0.002\u20130.06\u00a0cm]) and ascending aorta (0.04\u00a0cm [95% CI, 0.01\u20130.06\u00a0cm]) diameters. Higher standardized nadir CD4 (cluster of differentiation 4) T\u2010cell count was significantly associated with smaller aortic root (\u22120.03\u00a0cm [95% CI, \u22120.05 to \u22120.01\u00a0cm]), sinotubular junction (\u22120.03\u00a0cm [95% CI, \u22120.05 to \u22120.01\u00a0cm]), and ascending aorta (\u22120.03\u00a0cm [95% CI, \u22120.05 to \u22120.004\u00a0cm]) diameters. Higher levels of standardized TNF\u2010\u03b1 (tumor necrosis factor\u2010\u03b1) were associated with larger diameters of the aortic annulus (0.02\u00a0cm [95% CI, 0.003\u20130.04\u00a0cm]) and sinotubular junction (0.02\u00a0cm [95% CI, 0.002\u20130.04\u00a0cm]). There were no other cardiovascular or HIV disease severity\u2013related risk factors associated with the aortic dimensions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">HIV infection is an independent risk factor for greater ascending aortic sizes. Lower nadir CD4 T\u2010cell count and higher TNF\u2010\u03b1 levels are associated with larger aortic sizes in men with HIV.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT00046280.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.023997","type":"journal-article","created":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T10:51:19Z","timestamp":1646477479000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Association of HIV Serostatus and Inflammation With Ascending Aortic Size"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6680-0404","authenticated-orcid":false,"given":"Anum S.","family":"Minhas","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Medicine Johns Hopkins University School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8655-5204","authenticated-orcid":false,"given":"Wendy S.","family":"Post","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Johns Hopkins University School of Medicine Baltimore MD"},{"name":"Department of Epidemiology Johns Hopkins University Bloomberg School of Public Health Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins University Bloomberg School of Public Health Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9758-2240","authenticated-orcid":false,"given":"Henrique","family":"Doria De Vasconcellos","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Johns Hopkins University School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9467-3454","authenticated-orcid":false,"given":"Sabina A.","family":"Haberlen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins University Bloomberg School of Public Health Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8958-7666","authenticated-orcid":false,"given":"Matthew","family":"Feinstein","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0388-5460","authenticated-orcid":false,"given":"Valentina","family":"Stosor","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9616-1946","authenticated-orcid":false,"given":"Matthew","family":"Budoff","sequence":"additional","affiliation":[{"name":"Lundquist Institute at Harbor\u2010University of California Los Angeles Medical Center Torrance CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4865-4348","authenticated-orcid":false,"given":"Kara W.","family":"Chew","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases David Geffen School of Medicine at University of California Los Angeles Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5075-3604","authenticated-orcid":false,"given":"Jared W.","family":"Magnani","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Pittsburgh Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Medicine Johns Hopkins University School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8756-6995","authenticated-orcid":false,"given":"Joao A. C.","family":"Lima","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Johns Hopkins University School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4958-5145","authenticated-orcid":false,"given":"Katherine C.","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Johns Hopkins University School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000695"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.5830\/CVJA-2015-017"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2017.08.099"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.08.039"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000154569.08857.7A"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/126.2.310"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.019709"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000545"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-002-6690-0"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab348"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2018.07.053"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3181d4739e"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu281"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.04.094"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.121.023997","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:41:13Z","timestamp":1715600473000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.121.023997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,15]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,3,15]]}},"alternative-id":["10.1161\/JAHA.121.023997"],"URL":"https:\/\/doi.org\/10.1161\/jaha.121.023997","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,15]]},"assertion":[{"value":"2021-09-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e023997"}}