{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:25:36Z","timestamp":1785860736781,"version":"3.56.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,1,18]]},"abstract":"<jats:sec xml:lang=\"en\"><jats:title>Background<\/jats:title><jats:p xml:lang=\"en\">The rate of sudden cardiac death (SCD) in Brugada syndrome (BrS) is \u22481%\/y. Noninvasive electrocardiographic imaging is a noninvasive mapping system that has a role in assessing BrS depolarization and repolarization abnormalities. This study aimed to analyze electrocardiographic imaging parameters during ajmaline test (AJT).<\/jats:p><\/jats:sec><jats:sec xml:lang=\"en\"><jats:title>Methods and Results<\/jats:title><jats:p xml:lang=\"en\">All consecutive epicardial maps of the right ventricle outflow tract (RVOT\u2010EPI) in BrS with CardioInsight were retrospectively analyzed. (1) RVOT\u2010EPI activation time (RVOT\u2010AT); (2) RVOT\u2010EPI recovery time, and (3) RVOT\u2010EPI activation\u2010recovery interval (RVOT\u2010ARI) were calculated. \u2206RVOT\u2010AT, \u2206RVOT\u2010EPI recovery time, and \u2206RVOT\u2010ARI were defined as the difference in parameters before and after AJT. SCD\u2010BrS patients were defined as individuals presenting a history of aborted SCD. Thirty\u2010nine patients with BrS were retrospectively analyzed and 12 patients (30.8%) were SCD\u2010BrS. After AJT, an increase in both RVOT\u2010AT [105.9\u00a0milliseconds versus 65.8\u00a0milliseconds,<jats:italic>P<\/jats:italic>&lt;0.001] and RVOT\u2010EPI recovery time [403.4\u00a0milliseconds versus 365.7\u00a0milliseconds,<jats:italic>P<\/jats:italic>&lt;0.001] was observed. No changes occurred in RVOT\u2010ARI [297.5\u00a0milliseconds versus 299.9\u00a0milliseconds,<jats:italic>P<\/jats:italic>=0.7]. Before AJT no differences were observed between SCD\u2010BrS and non SCD\u2010BrS in RVOT\u2010AT, RVOT\u2010EPI recovery time, and RVOT\u2010ARI (<jats:italic>P<\/jats:italic>=0.9,<jats:italic>P<\/jats:italic>=0.91,<jats:italic>P<\/jats:italic>=0.86, respectively). Following AJT, SCD\u2010BrS patients showed higher RVOT\u2010AT, higher \u2206RVOT\u2010AT, lower RVOT\u2010ARI, and lower \u2206RVOT\u2010ARI (<jats:italic>P<\/jats:italic>&lt;0.001,<jats:italic>P<\/jats:italic>&lt;0.001,<jats:italic>P<\/jats:italic>=0.007,<jats:italic>P<\/jats:italic>=0.002, respectively). At the univariate logistic regression, predictors of SCD\u2010BrS were the following: RVOT\u2010AT after AJT (specificity: 0.74, sensitivity 1.00, area under the curve 0.92); \u2206RVOT\u2010AT (specificity: 0.74, sensitivity 0.92, area under the curve 0.86); RVOT\u2010ARI after AJT (specificity 0.96, sensitivity 0.58, area under the curve 0.79), and \u2206RVOT\u2010ARI (specificity 0.85, sensitivity 0.67, area under the curve 0.76).<\/jats:p><\/jats:sec><jats:sec xml:lang=\"en\"><jats:title>Conclusions<\/jats:title><jats:p xml:lang=\"en\">Noninvasive electrocardiographic imaging can be useful in evaluating the results of AJT in BrS.<\/jats:p><\/jats:sec>","DOI":"10.1161\/jaha.121.024001","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T12:50:51Z","timestamp":1642078251000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Ajmaline\u2010Induced Abnormalities in Brugada Syndrome: 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