{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:00:24Z","timestamp":1784304024212,"version":"3.55.0"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,5,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Given that percutaneous coronary intervention (PCI) of a chronic total occlusion (CTO) is indicated primarily for symptom relief, identifying patients most likely to benefit is critically important for patient selection and shared decision\u2010making. Therefore, we identified factors associated with residual angina frequency after CTO PCI and developed a model to predict postprocedure anginal burden.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Among patients in the OPEN\u2010CTO (Outcomes, Patient Health Status, and Efficiency in Chronic Total Occlusion Hybrid Procedures) registry, we evaluated the association between patient characteristics and residual angina frequency at 6\u00a0months, as assessed by the Seattle Angina Questionnaire Angina Frequency Scale. We then constructed a prediction model for angina status after CTO PCI using ordinal regression. Among 901 patients undergoing CTO PCI, 28% had no angina, 31% had monthly angina, 30% had weekly angina, and 12% had daily angina at baseline. Six months later, 53% of patients had a \u226520\u2010point increase in Seattle Angina Questionnaire Angina Frequency Scale score. The final model to predict residual angina after CTO PCI included baseline angina frequency, baseline nitroglycerin use frequency, dyspnea symptoms, depressive symptoms, number of antianginal medications, PCI indication, and presence of multiple CTO lesions and had a C index of 0.78. Baseline angina frequency and nitroglycerin use frequency explained 71% of the predictive power of the model, and the relationship between model components and angina improvement at 6\u00a0months varied by baseline angina status.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">A 7\u2010component OPEN\u2010AP (OPEN\u2010CTO Angina Prediction) score can predict angina improvement and residual angina after CTO PCI using variables commonly available before intervention. These findings have implications for appropriate patient selection and counseling for CTO PCI.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.024056","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T09:13:57Z","timestamp":1652692437000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Predicting Residual Angina After Chronic Total Occlusion Percutaneous Coronary Intervention: Insights from the OPEN\u2010CTO Registry"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6937-4041","authenticated-orcid":false,"given":"Neel M.","family":"Butala","sequence":"first","affiliation":[{"name":"Richard A. and Susan F. 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Aaron","family":"Grantham","sequence":"additional","affiliation":[{"name":"Saint Luke\u2019s Mid America Heart Institute\/UMKC Kansas City MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2839-2611","authenticated-orcid":false,"given":"John A.","family":"Spertus","sequence":"additional","affiliation":[{"name":"Saint Luke\u2019s Mid America Heart Institute\/UMKC Kansas City MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9163-724X","authenticated-orcid":false,"given":"David J.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7136-4464","authenticated-orcid":false,"given":"Philip","family":"Jones","sequence":"additional","affiliation":[{"name":"Saint Luke\u2019s Mid America Heart Institute\/UMKC Kansas City MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam C.","family":"Salisbury","sequence":"additional","affiliation":[{"name":"Saint Luke\u2019s Mid America Heart Institute\/UMKC Kansas City MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3367-0302","authenticated-orcid":false,"given":"Suzanne V.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Saint Luke\u2019s Mid America Heart Institute\/UMKC Kansas City MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Harrell","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Vanderbilt University School of Medicine Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Karmpaliotis","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8842-7919","authenticated-orcid":false,"given":"Jeffrey","family":"Moses","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3992-6815","authenticated-orcid":false,"given":"James","family":"Sapontis","sequence":"additional","affiliation":[{"name":"Monash Heart Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0564-4468","authenticated-orcid":false,"given":"Robert W.","family":"Yeh","sequence":"additional","affiliation":[{"name":"Richard A. and Susan F. 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