{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:15:21Z","timestamp":1793330121393,"version":"4.5.0"},"reference-count":60,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,8,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Ventricular performance is temporarily reduced following surgical atrial septal defect closure. Cardiopulmonary bypass and changes in loading conditions are considered important factors, but this phenomenon is incompletely understood. We aim to characterize biventricular performance following surgical and percutaneous atrial septal defect closure and to relate biomarkers to ventricular performance following intervention.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In this multicenter prospective study, children scheduled for surgical or percutaneous atrial septal defect closure were included. Subjects were assessed preoperatively, in the second week postintervention (at 2\u2010weeks follow\u2010up), and 1\u2010year postintervention (1\u2010year follow\u2010up). At each time point, an echocardiographic study and a panel of biomarkers were obtained. Sixty\u2010three patients (median age, 4.1 [interquartile range, 3.1\u20136.1] years) were included. Forty\u2010three patients underwent surgery. At 2\u2010weeks follow\u2010up, right ventricular global longitudinal strain was decreased for the surgical, but not the percutaneous, group (\u221217.6\u00b14.1 versus \u221227.1\u00b13.4;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). A smaller decrease was noted for left ventricular global longitudinal strain at 2\u2010weeks follow\u2010up for the surgical group (surgical versus percutaneous, \u221218.6\u00b13.2 versus \u221220.2\u00b12.4;\n              <jats:italic>P<\/jats:italic>\n              =0.040). At 1\u2010year follow\u2010up, left ventricular performance returned to baseline, whereas right ventricular performance improved, but did not reach preintervention levels. Eight biomarkers relating to cardiovascular and immunological processes differed across study time points. Of these biomarkers, only NT\u2010proBNP (N\u2010terminal pro\u2010B\u2010type natriuretic peptide) correlated with less favorable left ventricular global longitudinal strain at 2\u2010weeks follow\u2010up.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Right, and to a lesser degree left, ventricular performance was reduced early after surgical atrial septal defect closure. Right ventricular performance at 1\u2010year follow\u2010up remained below baseline levels. Several biomarkers showed a pattern over time similar to ventricular performance. These biomarkers may provide insight into the processes that affect ventricular function.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.trialregister.nl\/\">https:\/\/www.trialregister.nl\/<\/jats:ext-link>\n              ; Unique identifier: NL5129\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.024072","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T09:15:28Z","timestamp":1659690928000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Functional Echocardiographic and Serum Biomarker Changes Following Surgical and Percutaneous Atrial Septal Defect Closure in Children"],"prefix":"10.1161","volume":"11","author":[{"given":"Jelle P. 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