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We implemented a tilt paradigm to (1) investigate the acute hemodynamic response across a range of directions of the gravitational vector, and (2) to generate specific dose\u2010response relationships of this gravitational dependency.<\/jats:p><\/jats:sec><jats:sec xml:lang=\"en\"><jats:title>Methods and Results<\/jats:title><jats:p xml:lang=\"en\">Twelve male subjects were tilted from 45\u00b0 head\u2010up tilt to 45\u00b0 head\u2010down tilt in 15\u00b0 increments, in both supine and prone postures. We measured the steady\u2010state hemodynamic response in a range of variables including heart rate, stroke volume, cardiac output, oxygen consumption, total peripheral resistance, blood pressure, and autonomic indices derived from heart rate variability analysis. There is a strong gravitational dependence in almost all variables considered, with the exception of oxygen consumption, whereas systolic blood pressure remained controlled to within \u22483% across the tilt range. Hemodynamic responses are primarily driven by differential loading on the baroreflex receptors, combined with differences in venous return to the heart. Thorax compression in the prone position leads to reduced venous return and increased sympathetic nervous activity, raising heart rate, and systemic vascular resistance while lowering cardiac output and stroke volume.<\/jats:p><\/jats:sec><jats:sec xml:lang=\"en\"><jats:title>Conclusions<\/jats:title><jats:p xml:lang=\"en\">Gravitational dose\u2010response curves generated from these data provide a comprehensive baseline from which to assess the efficacy of potential spaceflight countermeasures. Results also assist clinical management of terrestrial surgery in prone posture or head\u2010down tilt positions.<\/jats:p><\/jats:sec>","DOI":"10.1161\/jaha.121.024175","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T11:14:57Z","timestamp":1657019697000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":47,"title":["Gravitational Dose\u2010Response Curves for Acute Cardiovascular Hemodynamics and Autonomic Responses in a Tilt Paradigm"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7437-5433","authenticated-orcid":false,"given":"Richard S.","family":"Whittle","sequence":"first","affiliation":[{"name":"Department of Aerospace Engineering Texas A&amp;M University College Station TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9742-5010","authenticated-orcid":false,"given":"Nathan","family":"Keller","sequence":"additional","affiliation":[{"name":"Department of Health and Kinesiology Texas A&amp;M University College Station TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4301-6964","authenticated-orcid":false,"given":"Eric A.","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Texas A&amp;M University College Station TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8989-4167","authenticated-orcid":false,"given":"Hrudayavani S.","family":"Vellore","sequence":"additional","affiliation":[{"name":"Department of Aerospace Engineering Texas A&amp;M University College Station TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7743-2800","authenticated-orcid":false,"given":"Lindsay M.","family":"Stapleton","sequence":"additional","affiliation":[{"name":"Department of Aerospace Engineering Texas A&amp;M University College Station TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1684-7121","authenticated-orcid":false,"given":"Katherine H.","family":"Findlay","sequence":"additional","affiliation":[{"name":"Independent Researcher College Station TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie J.","family":"Dunbar","sequence":"additional","affiliation":[{"name":"Department of Aerospace Engineering Texas A&amp;M University College Station TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0459-9327","authenticated-orcid":false,"given":"Ana","family":"Diaz\u2010Artiles","sequence":"additional","affiliation":[{"name":"Department of Aerospace Engineering Texas A&amp;M University College Station TX"},{"name":"Department of Health and Kinesiology Texas A&amp;M University College Station TX"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00727.2020"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2009.07.005"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.284869"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2009.03.008"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2009.05.006"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.81.1.19"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.186650"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-019-00657-1"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","unstructured":"Iwase S Nishimura N Tanaka K Mano T. 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