{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T05:19:04Z","timestamp":1793683144165,"version":"4.5.1"},"reference-count":65,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,3,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">This study examined the associations between quantitative optical coherence tomography angiography (OCTA) parameters and myocardial abnormalities as documented on cardiovascular magnetic resonance imaging in patients with systemic hypertension.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We conducted a cross\u2010sectional study of 118 adults with hypertension (197 eyes). Patients underwent cardiovascular magnetic resonance imaging and OCTA (PLEX Elite 9000, Carl Zeiss Meditec). Associations between OCTA parameters (superficial and deep retinal capillary density) and adverse cardiac remodeling (left ventricular mass, remodeling index, interstitial fibrosis, global longitudinal strain, and presence of left ventricular hypertrophy) were studied using multivariable linear regression analysis with generalized estimating equations. Of the 118 patients with hypertension enrolled (65% men; median [interquartile range] age, 59 [13] years), 29% had left ventricular hypertrophy. After adjusting for age, sex, systolic blood pressure, diabetes, and signal strength of OCTA scans, patients with lower superficial capillary density had significantly higher left ventricular mass (\u03b2=\u22120.150; 95% CI, \u22120.290 to \u22120.010), higher interstitial volume (\u03b2=\u22120.270; 95% CI, \u22120.535 to \u22120.0015), and worse global longitudinal strain (\u03b2=\u22120.109; 95% CI, \u22120.187 to \u22120.032). Lower superficial capillary density was found in patients with hypertension with replacement fibrosis versus no replacement fibrosis (16.53\u00b10.64\u00a0mm\n              <jats:sup>\u20101<\/jats:sup>\n              versus 16.96\u00b10.64\u00a0mm\n              <jats:sup>\u20101<\/jats:sup>\n              ;\n              <jats:italic>P<\/jats:italic>\n              =0.003).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">We showed significant correlations between retinal capillary density and adverse cardiac remodeling markers in patients with hypertension, supporting the notion that the OCTA could provide a non\u2010invasive index of microcirculation alteration for vascular risk stratification in people with hypertension.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.024226","type":"journal-article","created":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T10:53:54Z","timestamp":1646477634000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":34,"title":["Relationship of Quantitative Retinal Capillary Network and Myocardial Remodeling in Systemic Hypertension"],"prefix":"10.1161","volume":"11","author":[{"given":"Jacqueline","family":"Chua","sequence":"first","affiliation":[{"name":"Singapore Eye Research InstituteSingapore National Eye Centre Singapore Singapore"},{"name":"Academic Clinical Program Duke\u2010NUS Medical School National University of Singapore Singapore Singapore"},{"name":"SERI\u2010NTU Advanced Ocular Engineering (STANCE) Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thu\u2010Thao","family":"Le","sequence":"additional","affiliation":[{"name":"Academic Clinical Program Duke\u2010NUS Medical School National University of Singapore Singapore Singapore"},{"name":"National Heart Research Institute SingaporeNational Heart Centre Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9643-9266","authenticated-orcid":false,"given":"Yin Ci","family":"Sim","sequence":"additional","affiliation":[{"name":"Singapore Eye Research InstituteSingapore National Eye Centre Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9709-5680","authenticated-orcid":false,"given":"Hui Yi","family":"Chye","sequence":"additional","affiliation":[{"name":"Singapore Eye Research InstituteSingapore National Eye Centre Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyao","family":"Tan","sequence":"additional","affiliation":[{"name":"Singapore Eye Research InstituteSingapore National Eye Centre Singapore Singapore"},{"name":"SERI\u2010NTU Advanced Ocular Engineering (STANCE) Singapore Singapore"},{"name":"School of Chemical and Biomedical Engineering Nanyang Technological University Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8813-4676","authenticated-orcid":false,"given":"Xinwen","family":"Yao","sequence":"additional","affiliation":[{"name":"Singapore Eye Research InstituteSingapore National Eye Centre Singapore Singapore"},{"name":"SERI\u2010NTU Advanced Ocular Engineering (STANCE) Singapore Singapore"},{"name":"School of Chemical and Biomedical Engineering Nanyang Technological University Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damon","family":"Wong","sequence":"additional","affiliation":[{"name":"Singapore Eye Research InstituteSingapore National Eye Centre Singapore Singapore"},{"name":"SERI\u2010NTU Advanced Ocular Engineering (STANCE) Singapore Singapore"},{"name":"School of Chemical and Biomedical Engineering Nanyang Technological University Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Briana W. 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