{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:10:05Z","timestamp":1780549805246,"version":"3.54.1"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,7,5]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">An increase in beat\u2010to\u2010beat variability of repolarization (BVR) predicts arrhythmia onset in experimental models, but its clinical translation is not well established. We investigated the temporal changes in BVR before nonsustained ventricular tachycardia (nsVT) in patients with implantable cardioverter defibrillator (ICD).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Patients with nsVT on 24\u2010hour Holter before ICD implantation for ischemic cardiomyopathy (ischemic cardiomyopathy+nsVT, n=43) or dilated cardiomyopathy (dilated cardiomyopathy+nsVT, n=37), matched ICD candidates without nsVT (ischemic cardiomyopathy\u2010nsVT, n=29 and dilated cardiomyopathy\u2010nsVT, n=26), and patients without ICD without structural heart disease (n=50) were studied. Digital Holter recordings from these patients were analyzed using a modified fiducial segment averaging technique to detect the QT interval. The nsVT episodes were semi\u2010automatically identified and QT\u2010BVR was assessed 1\u2010, 5\u2010, and 30\u2010minutes before nsVT, and at rest (at 3:00\u00a0\n              <jats:sc>am<\/jats:sc>\n              ). Resting BVR was higher in ICD patients compared with controls without structural heart disease. In ICD patients with nsVT, BVR increased significantly 1\u2010minute pre\u2010nsVT in ischemic cardiomyopathy (2.21\u00b10.59\u00a0ms, versus 5 minutes pre\u2010nsVT: 1.78\u00b10.50\u00a0ms,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and dilated cardiomyopathy (2.09\u00b10.57\u00a0ms, versus 5\u2010minutes pre\u2010nsVT: 1.58\u00b10.51\u00a0ms,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), but not in patients without nsVT. In multivariable Cox regression analysis, pre\u2010nsVT BVR was a significant predictor for appropriate therapy during follow\u2010up.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Baseline BVR is elevated and temporal changes in BVR predict imminent nsVT events in patients with ICD independent of underlying cause. Real\u2010time BVR monitoring could be used to predict impending ventricular arrhythmia and allow preventive therapy to be incorporated into ICDs.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.024294","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T10:33:16Z","timestamp":1655893996000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Temporal Changes in Beat\u2010to\u2010Beat Variability of Repolarization Predict Imminent Nonsustained Ventricular Tachycardia in Patients With Ischemic and Nonischemic Dilated Cardiomyopathy"],"prefix":"10.1161","volume":"11","author":[{"given":"Matthew","family":"Amoni","sequence":"first","affiliation":[{"name":"Cardiology University Hospitals Leuven Leuven Belgium"},{"name":"Experimental Cardiology, Department of Cardiovascular Sciences University of Leuven 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