{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T21:17:13Z","timestamp":1780435033421,"version":"3.54.1"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,5,16]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The secondary prevention with pharmacologic therapy is essential for preventing recurrent cardiovascular events in patients experiencing acute myocardial infarction. Guideline\u2010based optimal medical therapy (OMT) for patients with acute myocardial infarction consists of antiplatelet therapy, angiotensin\u2010converting enzyme inhibitors\/angiotensin II receptor blockers, \u03b2\u2010blockers, and statins. We aimed to determine the prescription rate of OMT use at discharge and to evaluate the impact of OMT on long\u2010term clinical outcomes in patients with acute myocardial infarction who underwent percutaneous coronary intervention in the drug\u2010eluting stent era using nationwide cohort data.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Using the National Health Insurance claims data in South Korea, patients with acute myocardial infarction who had undergone percutaneous coronary intervention with a drug\u2010eluting stent between July 2013 and June 2017 were enrolled. A total of 35\u2009972 patients were classified into the OMT and non\u2010OMT groups according to the post\u2013percutaneous coronary intervention discharge medication. The primary end point was all\u2010cause death, and the 2 groups were compared using a propensity\u2010score matching analysis. Fifty\u2010seven percent of patients were prescribed OMT at discharge. During the follow\u2010up period (median, 2.0\u2009years [interquartile range, 1.1\u20133.2\u2009years]), OMT was associated with a significant reduction in the all\u2010cause mortality (adjusted hazard ratio [aHR], 0.82 [95% CI, 0.76\u20130.90];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and composite outcome of death or coronary revascularization (aHR, 0.89 [95% CI, 0.85\u20130.93];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">OMT was prescribed at suboptimal rates in South Korea. However, our nationwide cohort study showed that OMT has a benefit for long\u2010term clinical outcomes on all\u2010cause mortality and composite outcome of death or coronary revascularization after percutaneous coronary intervention in the drug\u2010eluting stent era.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.024370","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T11:18:37Z","timestamp":1683631117000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Evidence\u2010Based Optimal Medical Therapy and Mortality in Patients With Acute Myocardial Infarction After Percutaneous Coronary Intervention"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0149-5503","authenticated-orcid":false,"given":"Kyusup","family":"Lee","sequence":"first","affiliation":[{"name":"Cardiovascular Research Institute for Intractable Disease, College of Medicine The Catholic University of Korea Seoul Republic of Korea"},{"name":"Department of Cardiology, Daejeon St. Mary\u2019s Hospital, College of Medicine The Catholic University of Korea Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2938-8072","authenticated-orcid":false,"given":"Seungbong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, College of Medicine Korea University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0658-4081","authenticated-orcid":false,"given":"Myunhee","family":"Lee","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute for Intractable Disease, College of Medicine The Catholic University of Korea Seoul Republic of Korea"},{"name":"Department of Cardiology, Daejeon St. Mary\u2019s Hospital, College of Medicine The Catholic University of Korea Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2219-1835","authenticated-orcid":false,"given":"Dae\u2010Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute for Intractable Disease, College of Medicine The Catholic University of Korea Seoul Republic of Korea"},{"name":"Department of Cardiology, Daejeon St. Mary\u2019s Hospital, College of Medicine The Catholic University of Korea Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongbum","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Daejeon St. Mary\u2019s Hospital The Catholic University of Korea Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5846-0606","authenticated-orcid":false,"given":"Gyung\u2010Min","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ulsan University Hospital University of Ulsan College of Medicine Ulsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5293-8461","authenticated-orcid":false,"given":"Mahn\u2010Won","family":"Park","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute for Intractable Disease, College of Medicine The Catholic University of Korea Seoul Republic of Korea"},{"name":"Department of Cardiology, Daejeon St. Mary\u2019s Hospital, College of Medicine The Catholic University of Korea Daejeon Republic of 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