{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:19:21Z","timestamp":1773872361415,"version":"3.50.1"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,5,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">There is limited information regarding the clinical use and effectiveness of IV sotalol in pediatric patients and patients with congenital heart disease, including those with severe myocardial dysfunction. A multicenter registry study was designed to evaluate the safety, efficacy, and dosing of IV sotalol.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">A total of 85 patients (age 1\u00a0day\u201336\u00a0years) received IV sotalol, of whom 45 (53%) had additional congenital cardiac diagnoses and 4 (5%) were greater than 18\u00a0years of age. In 79 patients (93%), IV sotalol was used to treat supraventricular tachycardia and 4 (5%) received it to treat ventricular arrhythmias. Severely decreased cardiac function by echocardiography was seen before IV sotalol in 7 (9%). The average dose was 1\u00a0mg\/kg (range 0.5\u20131.8\u00a0mg\/kg\/dose) over a median of 60\u00a0minutes (range 30\u2013300\u00a0minutes). Successful arrhythmia termination occurred in 31 patients (49%, 95% CI [37%\u201362%]) with improvement in rhythm control defined as rate reduction permitting overdrive pacing in an additional 18 patients (30%, 95% CI [19%\u201341%]). Eleven patients (16%) had significant QTc prolongation to &gt;465\u00a0milliseconds after the infusion, with 3 (4%) to &gt;500\u00a0milliseconds. There were 2 patients (2%) for whom the infusion was terminated early.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">IV sotalol was safe and effective for termination or improvement of tachyarrhythmias in 79% of pediatric patients and patients with congenital heart disease, including those with severely depressed cardiac function. The most common dose, for both acute and maintenance dosing, was 1\u00a0mg\/kg over ~60\u00a0minutes with rare serious complications.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.024375","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T09:52:02Z","timestamp":1651485122000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["IV Sotalol Use in Pediatric and Congenital Heart Patients: A Multicenter Registry Study"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6392-9931","authenticated-orcid":false,"given":"Lindsey E.","family":"Malloy\u2010Walton","sequence":"first","affiliation":[{"name":"Children`s Mercy Hospital Kansas City MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9316-9416","authenticated-orcid":false,"given":"Nicholas H.","family":"Von Bergen","sequence":"additional","affiliation":[{"name":"University of Wisconsin Madison WI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seshadri","family":"Balaji","sequence":"additional","affiliation":[{"name":"Oregon Health and Science University Portland OR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter S.","family":"Fischbach","sequence":"additional","affiliation":[{"name":"Emory University School of Med\/CHOA Atlanta GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason M.","family":"Garnreiter","sequence":"additional","affiliation":[{"name":"Saint Louis University Saint Louis MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Yukiko","family":"Asaki","sequence":"additional","affiliation":[{"name":"University of Utah\/Primary Children's Hospital Salt Lake City UT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey P.","family":"Moak","sequence":"additional","affiliation":[{"name":"Children`s National Health System Washington DC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6156-610X","authenticated-orcid":false,"given":"Luis A.","family":"Ochoa","sequence":"additional","affiliation":[{"name":"University of Iowa Iowa City IA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6038-2712","authenticated-orcid":false,"given":"Philip M.","family":"Chang","sequence":"additional","affiliation":[{"name":"University of Florida\/Shands Children`s Hospital Gainesville FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6891-9951","authenticated-orcid":false,"given":"Hoang H.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Rush University Medical Center Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akash R.","family":"Patel","sequence":"additional","affiliation":[{"name":"UCSF Benioff Children's Hospital San Francisco CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christa","family":"Kirk","sequence":"additional","affiliation":[{"name":"Seattle Children's Hospital Seattle WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley K.","family":"Sherman","sequence":"additional","affiliation":[{"name":"Children`s Mercy Hospital Kansas City MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5295-1893","authenticated-orcid":false,"given":"Jennifer N.","family":"Avari Silva","sequence":"additional","affiliation":[{"name":"Washington University SOM Saint Louis MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7582-677X","authenticated-orcid":false,"given":"J. Philip","family":"Saul","sequence":"additional","affiliation":[{"name":"Department of Pediatrics West Virginia University School of Medicine Morgantown WV"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/16.1.81"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91048-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0b013e3181ea3184"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000316050"},{"key":"e_1_3_2_6_2","first-page":"4","article-title":"Efficacy of intravenous sotalol for treatment of incessant tachyarrhythmias in children","volume":"28","author":"Zhang Y","year":"2013","unstructured":"Zhang Y, Li X, Xu Z, Lui H. Efficacy of intravenous sotalol for treatment of incessant tachyarrhythmias in children. 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